Research paperMurine mucosal T cells have VIP receptors functionally distinct from those on intestinal epithelial cells
References (30)
- et al.
Selective localization of vasoactive intestinal peptide and substance P in human eosinophils
Biochem. Biophys. Res. Comm.
(1987) - et al.
The vasoactive intestinal peptide (VIP) receptor: recent data and hypothesis
Biochimie
(1988) - et al.
Comparison of vasoactive intestinal peptide-mediated protein phosphorylation in human lymphoblasts and colonic epithelial cells
Mol. Immunol.
(1989) - et al.
Pharmacological characterization of VIP receptors in human lung membranes
Peptides
(1988) - et al.
Characterization of immunomodulatory properties and accessory cell function of small intestinal epithelial cells
Cell. Immunol.
(1990) - et al.
Detection of vasoactive intestinal peptide and localization of its mRNA within granulomas of murine schistosomiasis
Cell. Immunol.
(1990) - et al.
Granulomas in murine schistosomiasis mansoni contain vasoactive intestinal peptide-responsive lymphocytes
Cell. Immunol.
(1991) - et al.
Recombinant murine IL-5 induces high rate IgA synthesis in cycling IgA-positive Peyer's patch B cells
J. Immunol.
(1988) Antigen presentation by gut epithelial cells: secretion by rat enterocytes of a factor with IL-1-like activity
Adv. Exp. Med. Biol.
(1987)- et al.
Maintenance of whole cell isoproterenol and forskolin responsiveness in adenylate cyclase of permeabilized cells
J. Cycl. Nucl. Prot. Phosphorylation Res.
(1986)
T cells in inductive and effector compartments of the intestinal mucosal immune system of nonhuman primates differ in lymphokine mRNA expression, lymphokine utilization, and regulatory function
J. Immunol.
The effect of IL-4 and IL-5 on the IgA response by murine Peyer's patch B cell subpopulations
J. Immunol.
Murine eosinophil differentiation factor: an eosinophilspecific colony-stimulating factor with activity for human cells
J. Exp. Med.
Lack of induction of suppressor T cells by intestinal epithelial cells from patients with inflammatory bowel disease
J. Clin. Invest.
Biochemical characteristics of receptors for vasoactive intestinal polypeptide in nervous, endocrine, and immune systems
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Molecular imaging probes derived from natural peptides
2016, Natural Product ReportsTarget-specific delivery of peptide-based probes for PET imaging
2010, Advanced Drug Delivery ReviewsCitation Excerpt :Having an essential histidine (His) residue at the N terminus and an amidated C terminus, all 28 amino acids of VIP are required for full biologic activity [165,166]. The gene receptors VPAC1 and VPAC2 have been detected on the cell membrane of normal intestinal [167,168] and bronchial epithelial cells [168,169] and are overexpressed on various tumor cells, including colonic adenocarcinomas [168–172], pancreatic carcinoma [173], and carcinoids [167]. Because of the hypothesis that VIP labeled with a suitable radionuclide can serve as a tool for molecular imaging and noninvasive, early scintigraphic detection of malignant lesions, VIP has been labeled with 64Cu for PET imaging.
TCR signaling and environment affect vasoactive intestinal peptide receptor-1 (VPAC-1) expression in primary mouse CD4 T cells
2008, Brain, Behavior, and ImmunityCitation Excerpt :Immune cells that express VIP receptors in proximity to VIP positive nerve endings can respond to a “neuro-delivered” biologically active ligand (Delgado et al., 1996; Goetzl et al., 1998; Cozzi, 1999). VIP sources can also be non-neuronal as Th2, but not Th1, CD4 T cells synthesize and secrete VIP, acting in an autocrine or paracrine manner, to support the Th2 immune response (Blum et al., 1992; Delgado and Ganea, 1999; Goetzl et al., 2001; Voice et al., 2001; Delgado and Ganea, 2001; Vassiliou et al., 2001). The immunomodulatory actions of this “neuro-cytokine-like” ligand, VIP, on T cells has been demonstrated to act by suppressing the crucial T cell growth factor, IL-2, through a VPAC-1 signaling cAMP-dependent mechanism (Wang et al., 2000).
Neuromuscular regulation of T-cell activation
1997, Journal of NeuroimmunologyMurine T-lymphocytes express vasoactive intestinal peptide receptor 1 (VIP-R1) mRNA
1996, Journal of Neuroimmunology