Metabolism of estrogens—natural and synthetic
References (259)
- et al.
Metabolism of 17α-ehynylestradiol and its 3-methyl ether by the rabbit; an in vivod-homoannulation
Steroids
(1969) - et al.
An orally long acting estrogen (AY-20121)
Steroids
(1970) - et al.
Interaction of 2-hydroxy-estrogens with enzymes of drug metabolism
J. Steroid Biochem.
(1976) The metabolism of natural estrogens
Vitamins and Hormones
(1962)- et al.
Effects of neomycin on the biliary exretion and enterohepatic circulation of mestranol and 17β-oestradiol
Biochem. Pharmacol.
(1977) - et al.
Radioimmunoassay of unconjugated plasma ethynylestradiol in women given a single oral dose of ethynylestradiol or mestranol
Steroids
(1975) - et al.
A histometric study of two estrogens: Ethynylestradiol and its 3-methyl ether derivative (mestranol); their comparative effect upon the growth of the human endometrium
Contraception
(1970) - et al.
Water-soluble metabolites of the estrogens. Quantitation of C-18-tetrols in rat feces
Steroids
(1976) - et al.
The interaction of steroids with liver microsomal cytochrome P-450—a genetal hypothesis
J. Steroid Biochem.
(1975) - et al.
Cyclopentyl ethers of estrogenic steroids: Parallelism between prolonged oral activity and storage in body fat of rats
J. Steroid Biochem.
(1972)
17 α-Ethynyl-17β-hydroxy-10α-estr-4-ene-3-one
Steroids
2-Hydroxyestrone, a new metabolite of estradiol in man
Arch. Biochem. Biophys.
Oxidative metabolism of estradiol
J. biol. Chem.
Identification and quantitative determination of 2-hydroxyoestriol in human late-pregnancy urine
J. Steroid Biochem.
Identification of 2-hydroxyestradiol and the pattern of catechol oestrogens in human pregnancy urine
J. Steroid Biochem.
Metabolism of radioactive 17α-ethynylestradiol by women
Steroids
Oestrogene und Lebererkrandkungen
Ostrogen metabolism in liver disease
J. Endocr.
Gas chromatographic and mass spectrometric studies on oestrogens in bile
Acta Endocr.
Effect of ampicilline administration on the excretion of twelve oestrogens in pregnancy urine
Acta Endocr.
The distribution of 14C-4-mestranol in mice
Acta pharmacol. toxicol.
Autoradiography of tritiated estramustine in castrated rats
Acta Pharmacol. Toxicol.
Steroid Drugs
A study on ovulation inhibition by quinestrol
Int. J. Fertility
Berkanntmachungen
Dtsch. Ärztebl.
Zur karzinogenen und teratogenen Wirkung von Diäthylstilböstrol
Dtsch. Ärztbel.
The natural oestrogenic hormone oestradiol as a new component of combined oral contraceptive
Br. med. J.
Methyltransferase enzymes in red blood cells
J. Pharmacol. Exp. Ther.
Interactions between estrogens and catecholamines
J. clin. Endocr. Metab.
Metabolism of 17α-ethynyl-414C-oestradiol and 4-14C-mestranol in rat liver slices and interaction between 17α-ethynyl-2-hydroxy-oestradiol and Adrenalin
Metabolism of oestradiol-17β and 2-hydoxyestradiol-17B in rat liver slices
Hoppe-Seyler's Z. physiol. Chem.
Metabolism of oestradiol and mestranol in man intraction between 2-hydroxy-ethynylestradiol and epineprine
Acta Endocr., Supp.
The excretion of 2-hydroxyestrone during the menstrual cycle
J. clin. Endocr. Metab.
Liver cell adenomas and oral contraceptives
New Engl. J. Med.
2,6-cis-Diphenylhexamethylcyclotetrasiloxane: Chemistry, analytical chemistry, biological effects and excretion
Acta Pharmacol. Toxicol.
Estrogenic activity of o,p′-DDT in the mammalian uterus and avian aviduct
Science
Metabolic clearance rates and metabolism of mestranol and ethynylestradiol in normal young women
J. clin Endocr. Metab.
Binding of diethylstilbestrol to desoxyribonucleic acid by rat liver microsomal fractions in vitro and in mouse of foetal cells in culture
Biochem. J.
Formation of estrogens from adrogens by human subcutaneous adipose tissue in vitro
Horm. Metab. Res.
Retention, metabolism and elimination of mestranol
Xenobiotica
The accumulation of mestranol and ethynylestradiol metabolites in the organism
Xenobiotica
The fate of mestranol in the isolated perfused rat liver
Horm. Metad.
Studies on the metabolism of ethynylestradion in vitro and in vivo
Xenobiotica
Pharmacokinetics of mestranol in man in relation to its oestrogenic activity
Europ. J. clin. Pharmacol.
Metabolism of 17α-ethynylestradiol by human liver microsomes in vitro: Aromatic hydroxylation and irreversible protein binding of metabolites
J. clin. Endocr. Metab.
Effect of rifampicin treatment on the metabolism of oestradiol and 17α-ethynyloestradiol by human liver microsomes
Eur. J. clin. Pharmacol.
Effects of insecticide synergists on microsomal oxidation of estradiol and ethynylestradiol and on microsomal drug metabolism
Xenobiotica
Interaction of rifampicin treatment with pharmacokinetics and metabolism and ethynyloestradiol in man
Acta Endocr.
Enterohepatischer Kreislauf und Sexualhormon-Stoffwechsel beim Meschen
Müch. Med. Wschr.
Die Ausscheidung von Androgenen und Östrogenen bei Gesunden und bei Patienten mit Niereninsuffizienz
Verh. Dtsch. Ges. inn. Med.
Cited by (126)
Identification of sex pheromone of red swamp crayfish Procambarus clarkii and exploration of the chemosensory mechanism of their antennae
2023, Pesticide Biochemistry and PhysiologyExposure to endocrine disruptors 17alpha-ethinylestradiol and estradiol influences cytochrome P450 1A1-mediated genotoxicity of benzo[a]pyrene and expression of this enzyme in rats
2018, ToxicologyCitation Excerpt :Expression of CYP enzymes of the family 1 (CYP1A1 and 1B1), which predominantly metabolise BaP, are known to be up-regulated by the aryl hydrocarbon receptor (AhR); BaP itself can bind to and activate AhR thereby enhancing its own metabolic activation (Hockley et al., 2007, 2008). Synthetic estrogen EE2 (Fig. 2) is widely used as a major component in oral contraceptives (Bolt, 1979). Incorporation of an acetylenic moiety into the estradiol molecule resulted in increased oral availability of the drug.
BODIPY-17α-ethynylestradiol conjugates: Synthesis, fluorescence properties and receptor binding affinities
2017, Bioorganic and Medicinal Chemistry LettersRole of rat cytochromes P450 in the oxidation of 17α-ethinylestradiol
2014, Environmental Toxicology and PharmacologyCitation Excerpt :Synthetic estrogen 17α-ethinylestradiol (EE2, Fig. 1A) belongs to the group of chemicals assigned as endocrine disruptive compounds, which disrupt endocrine system in wild life. This synthetic estrogen is widely used as the major component in oral contraceptives (OCs) (Bolt, 1979). Incorporation of an acetylenic moiety into the estradiol molecule (Fig. 1B) resulted in an increase in the oral availability of the drug.
The bioaccumulation and biotransformation of synthetic estrogen quinestrol in crucian carp
2014, Aquatic ToxicologyCitation Excerpt :For many animals, there is a suite of biotransformation enzymes in the liver or tissues associated with the processing of food, which are usually present in high levels (Livingstone, 1998). The enzymes may be significant to animals by reducing the estrogenic potency and increasing the polarity of estrogens for excretion or further metabolism (Bolt, 1979). The biotransformation of quinestrol to EE2 may have the same mechanism.