Original articleTissue factor expression in human leukemic cells
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2011, Blood Cells, Molecules, and DiseasesCitation Excerpt :In fact, patients with AML-M3 are at increased thrombotic risk and hemorrhagic complications following disseminated intravascular coagulation (DIC) [25]. These serious complications have been attributed to the aberrant expression of the clotting initiator protein, tissue factor (TF), in blast cells [26,27]. Treatment with ATRA down-regulates TF expression and reduces activation of blood coagulation in AML-M3 patients [28,29].
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