Cell
Volume 56, Issue 6, 24 March 1989, Pages 917-930
Journal home page for Cell

Article
Multistage carcinogenesis induced by ras and myc oncogenes in a reconstituted organ

https://doi.org/10.1016/0092-8674(89)90625-9Get rights and content

Abstract

ras and myc oncogenes were able to induce distinct phenotypic alterations, resembling different types of premalignant lesions, when introduced into approximately 0.1% of the cells used to reconstitute the mouse prostate gland. While ras induced dysplasia in combination with angiogenesis, myc induced a hyperplasia of the otherwise normally developed organ. ras and myc together induced primarily carcinomas. However, tumor progression was also associated with additional genetic alterations involving gene amplification. Our data indicate that specific types of benign premalignant lesions may reflect the activation of different single oncogenes, and that the consecutive activation of multiple oncogenes could be a causal event in the step-like progression of tumorigenesis.

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  • Cited by (0)

    Present address: Scott Department of Urology and Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030.

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