PaperEvaluation of annexin V as a platelet-directed thrombus targeting agent
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Nanomedicine progress in thrombolytic therapy
2020, BiomaterialsCitation Excerpt :Two years earlier, the same team published a work similarly dealing with LM-adsorbed micelles from triblock polymer – polycaprolactone-block-poly(2-(dimethylamino) ethyl methacrylate)-block-poly(2-hydroxyethyl methacrylate) (PCL-PDMAEMA-PHEMA) [110]. In a less common targeting strategy, Annexin V, a human phospholipid-binding protein that binds phosphatidylserine on the surface of activated platelets in a calcium-dependent manner and is proposed to play a role in the inhibition of blood coagulation [111], was conjugated to the micelles to target thrombi in a murine FeCl3-induced model and perform the in vivo thrombolytic activity. Poly(2-oxazoline) (POx).
An α<inf>IIb</inf>β<inf>3</inf>- And phosphatidylserine (PS)-binding recombinant fusion protein promotes PS-dependent anticoagulation and integrin-dependent antithrombosis
2019, Journal of Biological ChemistryCitation Excerpt :Cell surface–expressed PS is potentially an attractive target for TDD, especially for the prevention and treatment of platelet-derived thrombosis. ANV is a human protein that binds with high affinity and specificity to the abundant PS molecules exposed on activated platelets and accumulates selectively in thrombi after intravenous administration in animal models of arterial thrombosis (28). ANV is often used as a guiding molecule for targeting PS to construct potential recombinant protein drug candidates for the treatment of thrombotic diseases.
Multiplexed invivo fluorescence optical imaging of the therapeutic efficacy of photodynamic therapy
2013, BiomaterialsCitation Excerpt :It also implies a rapid blood clearance. The half-life of annexin V after intravenous injection is known to be less than 7 min [23,39,40]. Due to the high affinity (KD = 20 nm) and high specificity (reduction of fluorescence around 89% in a blocking experiment), our DY-734-annexin V probe was still able to efficiently and specifically detect the therapeutic efficacy of PDT at 2 days after treatment as our in vivo imaging data show.
Functional Imaging of Atherosclerosis to Advance Vascular Biology
2009, European Journal of Vascular and Endovascular SurgeryCitation Excerpt :Annexin V specifically binds, with nanomolar affinity, to phosphatidyl serine (PS), which is exposed on the surface of activated platelets35 and apoptotic cells.36 Therefore, radiolabelled 99mTc-annexin-V has been used for in vivo scintigraphic imaging of both apoptotic cells in animals and humans37 and acute or chronic platelet-rich thrombi in animals.38,39 In a recent study, we have shown the ability of 99mTc-annexin-V to assess the renewal activity of chronic aseptic intra-luminal thrombi, at the interface between circulating blood and thrombus, in an in vivo experimental model of AAA, and ex vivo in human ILT.37
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