The role of transferrins in gallium uptake

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Abstract

In certain animal tumor systems, transferrin appears to play a key role in the cellular uptake of radiogallium. This process is mediated by a transferrin receptor which is present on tumor cells. In vitro studies using tumor cells growing in tissue culture demonstrate that the uptake is saturable so that the rate of 67gallium uptake is dependent on the degree to which 67Ga-transferrin competes with non-labelled transferrin for binding to tumor cell associated transferrin receptors. Although the actual mechanism of this is not known, the evidence suggests that the 67Ga-transferrin complex is internalized into the cell, and that 67Ga is subsequently transferred to other subcellular macromolecules. Also, iron and gallium share a kinetically equivalent transport pathway.

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