Salivary and lacrimal gland involvement in a patient who had undergone a thyroidectomy and was treated with radioiodine for thyroid cancer

https://doi.org/10.1016/0030-4220(93)90144-SGet rights and content

Abstract

A patient with bilateral, insidiously developing enlargement of the parotid glands that started 1 year after a total thyroidectomy and ablative radioiodine therapy (200 mCi I131) for papillary carcinoma is presented. The patient displayed prolonged periods of hypothyroidism accompanied by hypercholesterolinemia, notwithstanding hormone replacement therapy. Three years after surgery, parotid and lacrimal gland functions were reduced and fatty degeneration of the parotid parenchyma was demonstrated histologically. The submandibular and sublingual glands were preserved. It is suggested that the hormonal and metabolic derangements are responsible for the glandular dysfunction, rather than a direct effect of iodine on the glands.

References (19)

There are more references available in the full text version of this article.

Cited by (41)

  • Radioprotective effect of montelukast sodium in rat lacrimal glands after radioiodine treatment

    2013, Revista Espanola de Medicina Nuclear e Imagen Molecular
    Citation Excerpt :

    Radioiodine (RAI, 131I) has been used for the treatment of hyperthyroidism and well-differentiated thyroid carcinomas.1 Some short-, intermediate- and long-term complications of RAI treatment have been identified.2–4 The short-term complications are xerostomia, nausea, gastralgia, pain in the thyroid bed, tenderness over the parotid gland and submandibular glands, change in taste and vomiting.4

  • Qualitative and quantitative changes in saliva among patients with thyroid dysfunction prior to and following the treatment of the dysfunction

    2013, Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
    Citation Excerpt :

    In our study, a lower SSFR (<1 mL/min) and salivary pH among hypothyroid subjects was observed. Earlier reports using radionuclide scintigraphy have similarly shown that hypothyroidism resulted in poorer salivary gland function.15-18,40 The present findings of low SSFR in our study also suggest reduced salivary gland function in hypothyroidism.

  • Sjögren syndrome and fibromyalgia after radioiodine therapy in cancer thyroid patients

    2011, Egyptian Rheumatologist
    Citation Excerpt :

    This is in agreement with the study of Solans et al. who reported that abnormal objective test results were more frequent than subjective symptoms when the salivary glands were evaluated [6]. Salivary gland dysfunction occurred in patients receiving low and high-dose radioiodine therapy [14–16,21,22]. In the present study, a reliance on total dose of radioiodine was significant for dysfunction and deterioration of the salivary parameters on follow up especially in patients receiving a total dose of >150 mCi.

View all citing articles on Scopus
View full text