Distribution of somatostatin receptors in normal and tumor tissue
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2016, Surgical Oncology Clinics of North AmericaCitation Excerpt :These G-protein-coupled receptors are normally expressed by neuroendocrine cells in a wide variety of tissue types, including the brain, pituitary, pancreas, thyroid, spleen, adrenal glands, large and small intestine, kidney, peripheral nervous system, immune cells, and the vasculature.99–101 SSTR2 is the most highly expressed SSTR subtype on most well-differentiated NETs and is the primary receptor for somatostatin-based imaging and treatment.99,102 There are 2 types of somatostatin receptor-based imaging available.