Elsevier

Life Sciences

Volume 59, Issue 16, 13 September 1996, Pages 1341-1349
Life Sciences

Localization of monoamine oxidases in human peripheral tissues

https://doi.org/10.1016/0024-3205(96)00459-6Get rights and content

Abstract

Localization of monoamine oxidases (MAO) A and B and β-adrenoceptors. was studied in aged human peripheral tissues (age 68–80 years) by quantitative autoradiography. The tissues analyzed were heart, lung, liver, kidney, spleen and duodenum. [3H]Ro41-l049 and [3H]lazabemide, two recently characterized selective radioligands, were used to map MAO-A and MAO-β respectively. The regional pattern of distribution of MAO-A and MAO-B did not differ markedly. except in kidney and especially in duodenum. Highest levels of MAOs were measured in liver. and lowest in spleen. MAO-A was more abundant than MAO-B in lung and duodenal mucosa, and the reverse was true in myocardium. These results show marked differences in the abundance and patterns of distribution of MAOs, particularly MAO-B, in human and rodent peripheral tissues.

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    Present Address of Miquel Vila: Laboratoire de Médecine Expérimentale, INSERM Unité 289, 75651 Paris, France.

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