Validation of transport measurements in skeletal muscle with N-13 amino acids using a rabbit isolated hindlimb model
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2018, Nuclear Medicine and BiologyCitation Excerpt :Unfortunately, the development of PET tracers based on glutamine has been held back partly due to its inevitable difficulty of radiolabeling when conventional 11C-labeling and 18F-labeling radiochemistry is considered [11,12]. Still, 13N-labeled glutamine and 11C-labeled glutamine were radiosynthesized and evaluated in vivo although their application was limited due to the short half-lives of N-13 (t1/2 = 10 min) and C-11 (t1/2 = 20 min) [13,14]. Hank F. Kung et al. established an elegant and sophisticated strategy of radiolabeling glutamine, and subsequently fully evaluated four stereo-isomeric 18F-labeled glutamine analogs as potential tracers [15-17], leaving substantially little space for further optimization using conventional strategies on this restricted structure of glutamine.
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