Research reportA novel immunoassay of smooth muscle myosin heavy chain in serum
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Carotid artery dissections: Thrombosis of the false lumen
2011, Thrombosis ResearchCitation Excerpt :This insult may result in progression of the dissection along the artery, or release of smooth muscle-associated structural proteins, such as smooth muscle myosin heavy chain, into the circulation. Immunoassays for plasma smooth muscle myosin heavy chain are currently being investigated for the diagnosis and management of arterial dissections [39–43]. Abnormal activation and signalling of transforming growth factor-β (TGF-β) are associated with dilatations and dissections, pulmonary emphysema, atrioventricular valve deformation and musculoskeletal myopathy [10,44].
Biomarkers in aortic dissection
2011, Clinica Chimica ActaDiagnosing acute aortic syndromes: The role of specific biochemical markers
2010, International Journal of CardiologyBiomarkers in acute aortic dissection and other aortic syndromes
2010, Journal of the American College of CardiologyCitation Excerpt :It is also present in uterine and intestinal smooth muscle and potentially could be elevated in conditions involving these systems. Preliminary experience by Katoh et al. in 1995 (21,22) suggested that smMHC is elevated within the first 24 h following AAD. Suzuki et al. (23) enrolled 27 patients with AAD (type A, n = 16), investigated 6.0 ± 1.3 h after symptom onset.
In search of blood tests for thoracic aortic diseases
2010, Annals of Thoracic SurgeryCitation Excerpt :Larger studies are needed to confirm the utility of this approach in the various cohorts of patients with acute and chronic aortic disease. Smooth muscle myosin heavy chain and its isoforms are structural proteins found in smooth muscle cells [28, 29]. Levels of smooth muscle myosin heavy chain protein can be used to diagnose aortic dissection soon after symptom onset with the use of a rapid 30-minute assay [28–30].
Acute aortic syndromes and thoracic aortic aneurysm
2009, Mayo Clinic ProceedingsCitation Excerpt :Smooth-muscle myosin, a specific form of myosin found in cells of the aortic media, is released into the circulation at the time of aortic wall damage. Previous studies have shown that serum smooth-muscle myosin heavy-chain protein levels peak within 24 hours of AAD and then are rapidly cleared, analogous to serum assays done to detect an acute myocardial infarction.53,54 According to the findings of these preliminary studies, smooth-muscle myosin heavy-chain protein shows promise as a potential laboratory biomarker for the detection of aortic dissection.