Research paperInheritability of atherosclerosis and the role of lipoproteins as risk factors in the development of atherosclerosis in WHHL rabbits: Risk factors related to coronary atherosclerosis are different from those related to aortic atherosclerosis
References (24)
- et al.
WHHL-rabbit: a low density lipoprotein receptor-deficient animal model for familial hypercholesterolemia
FEBS Lett.
(1980) - et al.
Increase in hepatic low density lipoprotein receptor activity during pregnancy in Watanabe heritable hyperlipidemic (WHHL) rabbits, an animal model for familial hypercholesterolemia
Biochim. Biophys. Acta
(1987) Serial inbreeding of rabbits with hereditary hyperlipidemia (WHHL rabbit): incidence and development of atherosclerosis and xanthoma
Atherosclerosis
(1980)- et al.
The effect of selective breeding in the development of coronary atherosclerosis in WHHL rabbits, an animal model for familial hypercholesterolemia
Atherosclerosis
(1985) - et al.
Coronary arterial dimensions and cell populations in ageing man
Atherosclerosis
(1988) - et al.
Practical methods for plasma lipoprotein analysis
Adv. Lipid Res.
(1968) - et al.
ApoVLDL of the Watanabe heritable hyperlipidemic rabbit and cholesterol-fed rabbit
J. Lipid Res.
(1984) - et al.
Characterization of very low density lipoprotein from Watanabe heritable hyperlipidemic rabbits
J. Lipid Res.
(1989) - et al.
Apolipoprotein E mediates the interaction of β-VLDL with macrophages
J. Lipid Res.
(1987) - et al.
Serum cholesterol, lipoproteins and the risk of coronary heart disease, The Framingham Study
Ann. Intem. Med.
(1971)
Coronary heart disease in seven countries
Circulation
The lipid research clinics coronary primary prevention trial results, I. Reduction in incidence of coronary heart disease
J. Am. Med. Assoc.
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Spontaneous severe hypercholesterolemia and atherosclerosis lesions in rabbits with deficiency of low-density lipoprotein receptor (LDLR) on exon 7
2018, EBioMedicineCitation Excerpt :For histological analysis, serial paraffin sections of aortic atherosclerosis lesions were stained with hematoxylin-eosin (HE), Masson Trichrome (MT) and immunohistochemically stained with monoclonal antibodies against either macrophages (Mφ) (clone: RAM11, Dako, Carpinteria, CA, US) or α-smooth muscle actin for smooth muscle cells (SMC) (clone: HHF35, Dako, Carpinteria, CA, US). According to the method reported elsewhere [45,46], the immersion-fixed hearts treated with formalin were cut into 6 blocks and embedded in paraffin. The left coronary artery was cross-sectioned (5 μm per slice), and sections were stained with H&E staining.
Contribution of the WHHL rabbit, an animal model of familial hypercholesterolemia, to elucidation of the anti-atherosclerotic effects of statins
2013, AtherosclerosisCitation Excerpt :To study cardiovascular disease in more detail, Dr. Watanabe started to develop a new line of WHHL rabbits, which had coronary lesions [2]. After two cycles of selective breeding, the incidence and degree of coronary plaques increased [2,12,13]. WHHL rabbits were then improved by the third selective breeding; leading to myocardial infarction-prone WHHL (WHHLMI) rabbits, which have inflamed thin-capped fibroatheroma in the coronary arteries (unstable coronary plaques), related to myocardial infarction [2,14].
Experimental models of atherosclerosis
2013, Revista Espanola de Cardiologia SuplementosAnimal models of atherosclerosis
2012, Progress in Molecular Biology and Translational ScienceMacrophage foam cell formation is augmented in serum from patients with diabetic angiopathy
2010, Diabetes Research and Clinical PracticeCitation Excerpt :The WHHLMI rabbit was developed from WHHL rabbits [9], which have a mutated LDL receptor and hypercholesterolemia, such that atherosclerosis develops rapidly [10,11]. The incidence of myocardial infarction in WHHL rabbits was low, while WHHLMI rabbits developed coronary occlusion and spontaneous myocardial infarction reportedly due to having higher amounts of apolipoprotein E-rich VLDL [12–14]. We investigated whether serum activities in diabetic patients inducing the differentiation of J774.1 cells into foam cells, differ according to patient features including metabolic control, development of angiopathic complications, drug treatments, and so on.
The Watanabe heritable hyperlipidemic (WHHL) rabbit, its characteristics and history of development: A tribute to the late Dr. Yoshio Watanabe
2009, AtherosclerosisCitation Excerpt :His successor attempted to achieve this final goal, the development of myocardial infarction. After a second round of selective breeding, WHHL rabbits with severe coronary atherosclerosis were obtained [48]. However, the incidence of ischemic myocardial lesions was still very low.