A new 68Ge/68Ga radioisotope generator system for production of 68Ga in dilute HCl

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Abstract

The synthesis of an ion-exchanger resin produced from pyrogallol and formaldehyde and characterized by a highly efficient adsorption for 68Ge is described. A 68Ge/68Ga radioisotope generator prepared from this resin and operated with 10 ml of 4.5n HCl as eluant constantly showed a high yield of 68Ga during a time period of more than 200 days with a contamination of less than 1 ppm 68Ge. A small column, filled with commercially available anion-exchanger resin and coupled in series with the generator, reduces the volume and HCl concentration of the generator eluate in such a way that 80% of the available 68Ga appears in 4 ml 0.5 N HCl. The eluate is free of radiolytic products and suitable for human use.

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This work is dedicated to Professor K.E. Scheer, director of the Institute of Nuclear Medicine, German Cancer Research Center, on the occasion of his 60th birthday.

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