The nature of the astatine-protein bond

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Abstract

The electrophilic astatination of a number of proteins is studied. Two types of binding of the astatine to the protein are observed: a relatively stable one in the case of SH containing proteins—probably by the formation of a SAt bond—and a weaker binding of a still unknown nature for proteins lacking a free SH-group. The two types of protein-astatine bond are destroyed by addition of sulphite, thio-sulphate, thiourea, cysteine, iodoacetamide, thiocyanate, Hg2+-salts and potassium iodide.

References (59)

  • K.A. Krohn et al.

    Biochim. Biophys. Acta

    (1977)
  • A.T.M. Vaughan et al.

    Int. J. Nucl. Med. Biol.

    (1978)
  • A.M. Friedman et al.

    Int. J. Nucl. Med. Biol.

    (1977)
  • G.W.M. Visser et al.

    Int. J. Appl. Radiat. Isot.

    (1979)
  • G.W.M. Visser et al.

    Int. J. Appl. Radiat. Isot.

    (1980)
  • G.W.M. Visser et al.

    Int. J. Nucl. Med. Biol.

    (1980)
  • D.R. Goddard et al.

    J. Biol. Chem.

    (1935)
  • M. Sela et al.

    Biochim. Biophys. Acta

    (1959)
  • K. Krohn et al.

    Biochim. Biophys. Acta

    (1977)
  • P.J. Fraker et al.

    Biochem. Biophys. Res. Commun.

    (1978)
  • A.T.M. Vaughan

    Int. J. Nucl. Med. Biol.

    (1980)
  • I.M. Klotz et al.

    J. Am. Chem. Soc.

    (1955)
  • P.A. Kober et al.

    J. Biol. Chem.

    (1912)
    Y. Sugiura et al.

    J. Am. Chem. Soc.

    (1975)
  • H. Rheinboldt et al.

    Chem. Ber.

    (1939)
  • H. Fraenkel-Conrat

    J. Biol. Chem.

    (1955)
  • W.L. Hughes et al.

    J. Am. Chem. Soc.

    (1950)
  • H. Fraenkel-Conrat

    Arch. Biochem. Biophys.

    (1950)
  • H. Fraenkel-Conrat et al.

    Arch. Biochem. Biophys.

    (1967)
  • L. Jirousek et al.

    Biochim. Biophys. Acta

    (1968)
  • L. Jirousek et al.

    Biochim. Biophys. Acta

    (1971)
  • L.K. Ramachandran

    Chem. Rev.

    (1956)
  • L. Fieser et al.

    Advanced Organic Chemistry

  • M.A. Slifkin et al.

    Int. J. Appl. Radiat. Isot.

    (1978)
  • V.I. Levin et al.

    Int. J. Appl. Radiat. Isot.

    (1980)
  • P. Brooks et al.

    J. Am. Chem. Soc.

    (1960)
  • M. Sivasankaran et al.

    Inorg. Chim. Acta

    (1980)
  • C. Aay et al.

    Int. J. Appl. Radiat. Isot.

    (1975)
  • G.W.M. Visser et al.

    Int. J. Appl. Radiat. Isot.

    (1981)
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