Gallium-67 and indium-111 radiopharmaceuticals

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Abstract

There are no compounds known to exist naturally in the human body which involve gallium or indium metal cofactors. In spite of this numerous compounds which contain 67Ga and 111In as their integral part have been prepared mainly for localization studies. One of the important considerations in these preparations has been the physical characteristics of 67Ga and 111In which are summarized together with the methods of their preparation.

Factors governing the chelation of organometallic radiopharmaceuticals, their in vivo stability and usefulness have been discussed. The compounds prepared have been reviewed and summarized together with the basic concept in their preparation. The results of their in vivo evaluations have been outlined and the merits for potential future applications of some of the compounds have been mentioned.

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    The article was written while on sabbatical at Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 South Kings-highway, St. Louis, MO 63110, U.S.A.

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