Rapid communicationExquisite delineation of 5-HT1A receptors in human brain with PET and [carbonyl-11C]WAY-100635
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Dopaminergic and serotonergic mechanisms in the modulation of pain: In vivo studies in human brain
2018, European Journal of PharmacologyVerbal memory and 5-HT<inf>1A</inf> receptors in healthy volunteers - A PET study with [carbonyl-<sup>11</sup>C]WAY-100635
2016, European NeuropsychopharmacologyCitation Excerpt :In addition to effects on verbal memory, there is preliminary evidence that 5-HT1A receptor agonism could also influence cognitive flexibility (Depoortere et al., 2007). Positron emission tomography (PET) with the radioligand [carbonyl-11C]WAY-100635 offers a tool to investigate the 5-HT1A receptors in humans in vivo (Pike et al., 1996). Between-subject variability in 5-HT1A receptor binding is large in normal subjects, the biological basis of which is mostly unclear (Borg et al., 2006; Parsey et al., 2002; Rabiner et al., 2002).
Neuroticism and serotonin 5-HT<inf>1A</inf> receptors in healthy subjects
2015, Psychiatry Research - NeuroimagingCitation Excerpt :5-HT1A receptors in the hippocampus also play a role in depression by regulating stress (Savitz et al., 2009). 5-HT1A receptors can be quantified in living human brain using PET and the antagonist radioligand [carbonyl-11C]WAY-100635 (Pike et al., 1996). Most studies on patients with mood and anxiety disorders have found decreased 5-HT1A binding potential (BPND), although studies in major depression are controversial and may be confounded by methodological factors (Shrestha et al., 2012).
In vivo occupancy of the 5-HT<inf>1A</inf> receptor by a novel pan 5-HT<inf>1(A/B/D)</inf> receptor antagonist, GSK588045, using positron emission tomography
2015, NeuropharmacologyCitation Excerpt :There are a number of possible explanations for this finding: (1) There could be a specific binding component of the [11C]WAY100635 signal in the cerebellum, which is reduced following a blocking dose of GSK588045. This is thought to be unlikely since the cerebellum is believed to have a low level of specific binding of [11C]WAY-100635 (Burnet et al., 1997; Hall et al., 1997), and whilst 5-HT1A is present in the vermis, the cerebellar hemispheres which are composed of largely of white matter have been shown to be devoid of 5-HT1A receptor binding (Parsey et al., 2005; Pazos et al., 1987; Pike et al., 1996); (2) There could be a “spill-over” of signal from brain adjacent areas into the cerebellum. This effect would be more pronounced during the baseline scans, and diminished in the blocked condition, resulting in an artificially high baseline signal in the cerebellum.
Increased binding of 5-HT<inf>1A</inf> receptors in a dissociative amnesic patient after the recovery process
2014, Psychiatry Research - Neuroimaging