Brain dialysis and dopamine: does the extracellular concentration of dopamine reflect synaptic release?
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Cited by (38)
Serotonin transporter availability in impulsive aggressive personality disordered patients: A PET study with [<sup>11</sup>C]DASB
2014, Journal of Psychiatric ResearchCitation Excerpt :Time activity curves were formed for each ROI by measuring the mean activity in the ROI in each frame. Limbic ROIs were the pgACC and amygdala and were drawn according to criteria based on brain atlases (Talairach and Tournoux, 1988; Duvernoy, 1991) and on published reports (Pani et al., 1990; Kates et al., 1997; Killiany et al., 1997) (for pgACC see also Fig. 1 in Frankle et al. (2005)). A gray/white tissue segmentation procedure (Abi-Dargham et al., 2002) was applied to the limbic regions so that only voxels classified as gray matter were included in these ROIs.
Serotonin transporter availability in patients with schizophrenia: A positron emission tomography imaging study with [<sup>11</sup>C]DASB
2005, Biological PsychiatryCitation Excerpt :Thus, each PET frame was resampled in the coronal plane to a voxel volume of 1.5 × .9 × .9 mm3. Regions of interest (ROIs, n = 10) and region of reference (cerebellum) boundaries were drawn on the MRI according to criteria derived from brain atlases (Duvernoy 1991; Talairach and Tournoux 1988) and published reports (Kates et al 1997; Killiany et al 1997; Mawlawi et al 2001; Pani et al 1990). Regions of interest included the midbrain (encompassing SERT-dense structures, such as the raphe nuclei, substantia nigra, locus coeruleus, ventral tegmental area, and superior and inferior colliculi), thalamus, dorsal caudate, dorsal putamen, ventral striatum, amygdala, entorhinal cortex, hippocampus, parahippocampal gyrus, and the anterior cingulate cortex.
Mechanisms of the effects of exogenous levodopa on the dopamine-denervated striatum
2001, NeuroscienceCitation Excerpt :However, only those rats showing marked aphagia/adipsia after the second lesion were selected, and these rats showed practical absence of TH immunoreactivity in both the right and left striatum; therefore, a slight remaining rotation towards the most recently lesioned side is attributable to incomplete development (i.e. one to two weeks postlesion) of hypersensitivity of the DA receptors on that striatum.23 Results indicating a direct action of exogenous l-DOPA on striatal DA receptors have suggested that in the DA denervated striatum, the liberation of DA from exogenous l-DOPA may occur extrasynaptically and may be ineffective, since any such DA may be unable to stimulate dopamine receptors postsynaptically.18,40,53,57 The present results, and particularly those showing Fos expression in striatal neurons, indicate that l-DOPA is converted to DA in the striatum (see above) and that this DA stimulates the striatal neurons.