Effect of aging in human cortical pre- and postsynaptic serotonin binding sites
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Which demographic variables are necessary to correct in neuroimaging studies of serotonin transporter availability? A SPECT study with [<sup>123</sup>I]ADAM
2015, Psychiatry Research - NeuroimagingCitation Excerpt :Also, the highly selective affinity of SERT as assessed with the [123I]ADAM radioligand mitigates against the possible confound of dual activity related to the dopamine transporter (DAT), which might otherwise influence the results, as DAT may be also influenced by age (Lavalaye et al., 2000). The influence of age on SERT was not conclusive in previous post-mortem (Allen et al., 1983; Arranz et al., 1993) or other in vivo neuroimaging studies (Dahlstrom et al., 2000; Buchert et al., 2006), and the lack of clarity may reflect limited sample sizes in previous studies and the use of different radioligands. In addition, the age range of the subject group may affect the results.
The serotonergic system in ageing and Alzheimer's disease
2012, Progress in NeurobiologyCitation Excerpt :However, other studies reported an age-associated increase in [3H]-imipramine binding site in the human hypothalamus, parietal cortex, frontal cortex, occipital cortex and the hippocampus (Owen et al., 1986; Severson et al., 1985). Moreover, binding studies using [3H]-paroxetine reported stable density of SERT expression in aged human frontal cortex (Arranz et al., 1993). On average, there is a 10% decrease per decade in the density of SERT binding sites in human brain stem and thalamus (Yamamoto et al., 2002).
[ <sup>11</sup>C]-DASB microPET imaging in the aged rat: Frontal and meso-thalamic increases in serotonin transporter binding
2011, Experimental GerontologyCitation Excerpt :Regarding the effects of age on the 5-HTT, human postmortem studies have rendered quite inconclusive results. The majority of postmortem research on this topic observed no age-associated changes in 5-HTT levels (Andersson et al., 1992; Arranz et al., 1993), although several studies report regional increments (Severson et al., 1985) or decrements (Marcusson et al., 1987) as well. Molecular imaging studies in humans, however, have predominantly found reductions in 5-HTT radioligand uptake in the diencephalon and midbrain (Hesse et al., 2003; Kuikka et al., 2001; Pirker et al., 2000; Yamamoto et al., 2002), although not all in vivo studies observed this effect (Ryding et al., 2004).
Neuroeconomics and aging: Neuromodulation of economic decision making in old age
2010, Neuroscience and Biobehavioral Reviews
The study was supported by grants from the Swedish Medical Research Council (B92-12X-08648-04B), the Stohne Foundation, Centrala Forsoksdjursnamnden and Gamla Tjanarinnor, the Swedish Society for Medicine, and FIS (93/0318).