Age-dependent decline in human brain dopamine D1 and D2 receptors
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2023, Behavioural Brain ResearchSynaptic density in healthy human aging is not influenced by age or sex: a <sup>11</sup>C-UCB-J PET study
2021, NeuroImageCitation Excerpt :The main afferent neurons to the dorsal striatum (caudate nucleus and putamen) are glutamatergic and dopaminergic, while striatal interneurons are mainly GABA-ergic and cholinergic (Galvan et al., 2006). It needs to be elucidated which of these neurotransmitter systems may be responsible for the decrease of synaptic density as the existing literature is inconclusive: depending on the neurotransmitter system studied and the subtype of receptor investigated, increases or decreases with healthy aging are described (Bauer et al., 2015; Bernácer et al., 2012; Rinne et al., 1990; Rozycka and Liguz-Lecznar, 2017; Tsamis et al., 2013; Wang et al., 1998; Wong et al., 1984), but none of these studies found an age effect limited to the caudate nucleus. However, one caveat needs to be mentioned since the caudate nucleus is a small structure adjacent to the lateral ventricles.
Older adults show a reduced tendency to engage in context-dependent decision biases
2020, NeuropsychologiaThe effects of age on reward magnitude processing in the monetary incentive delay task
2020, NeuroImageCitation Excerpt :In contrast, the ventrolateral prefrontal cortex appears to respond specifically to the anticipation of loss (Dugre et al., 2018). Aging is associated with altered striatocortical dopaminergic transmission (Berry et al., 2019; Dreher et al., 2008; Rinne et al., 1990; Volkow et al., 1998). Older as compared to younger adults show reduced VS activation to reward anticipation in variants of the MIDT (Dreher et al., 2008; Samanez-Larkin et al., 2007; Schott et al., 2007; Vink et al., 2015).