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The opioid system in depression
2022, Neuroscience and Biobehavioral ReviewsCitation Excerpt :While preclinical evidence has highlighted opioid associations with key processes associated with depression and positive effects of opioidergic drugs in rodent models of depression, there is always the need for caution in generalising findings from rodent models to humans (Harro, 2019; Stanford, 2020). Of particular relevance to the study of the opioid system, although opioid receptors follow a similar distribution pattern, there is relatively more KOR binding and relatively less DOR in humans compared with rodents (Pfeiffer et al., 1982). Furthermore, there are potential species differences in terms of KOR (Schattauer et al., 2012) and MOR (DeWire et al., 2013; Schmid et al., 2017) ligand effects on downstream signalling pathways.
Thalamic circuits
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2016, Neuropathology of Drug Addictions and Substance Misuse Volume 1: Foundations of Understanding, Tobacco, Alcohol, Cannabinoids and Opioids
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Present address: Laboratory of Clinical Science, National Institute of Health, Bethesda, MD 20205, U.S.A.