Elsevier

Biological Psychiatry

Volume 36, Issue 12, 15 December 1994, Pages 847-849
Biological Psychiatry

Brief report
Reduced plasma noradrenaline and abnormal heart rate variability in resting panic disorder patients

https://doi.org/10.1016/0006-3223(94)90596-7Get rights and content

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  • Cited by (31)

    • Altered autonomic reactivity in Korean military soldiers with adjustment disorder

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      Although the definition of very low frequency HRV and its components is still unclear (Otzenberger et al., 1998; Stein and Pu, 2012), a higher power of very low frequency HRV suggests a sympathetic overactivity in patients with adjustment disorder at baseline (Kember et al., 2001). Similar observations reflected by measuring the low frequency/high frequency ratio have been reported previously in various mental illnesses such as MDD (Agelink et al., 2002; Udupa et al., 2007), panic disorder (Yeragani et al., 1993; Middleton et al., 1994), and PTSD (Cohen et al., 1998). Moreover, one study reported a positive correlation between depression severity and the power of very low frequency HRV in both children and adolescents, which is in agreement with our results (Blood et al., 2015).

    • Subjective sleep quality in relation to inhibition and heart rate variability in patients with panic disorder

      2013, Journal of Affective Disorders
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      Accordingly, PD-patients report reduced sleep quality as measured by the Pittsburgh Sleep Quality Index (PSQI; Buysse et al., 1989) compared to healthy controls (Stein et al., 1993). These patients also show impaired inhibitory capacity (Dupont et al., 2000), and are characterised by decreased heart rate variability (HRV; Cohen et al., 2000; Middleton et al., 1994). Vagally mediated HRV is suggested to be an index of pre-frontal cortical (PFC) neuronal inhibitory activity (Thayer and Lane, 2000; Friedman, 2007), and this area, the PFC, is strongly implicated in executive functioning (Ridderinkhof et al., 2004).

    • The effect of anxiety on heart rate variability, depression, and sleep in Chronic Obstructive Pulmonary Disease

      2013, Journal of Psychosomatic Research
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      Autonomic dysregulation indexed by decreased HRV may help explain elevated levels of anxiety and depression in COPD patients. Additionally, patients with anxiety disorders and anxiety symptoms, including panic anxiety, generalized anxiety disorder, and panicogenic manipulations, may exhibit reduced HRV [19–30], suggesting that reduced HRV may be a physiological marker linked with clinical anxiety. However, no prior studies of COPD and HRV studies cited above [16–18] have addressed the role of anxiety in the relationship between COPD and autonomic dysregulation.

    • The relationships among heart rate variability, executive functions, and clinical variables in patients with panic disorder

      2012, International Journal of Psychophysiology
      Citation Excerpt :

      Due to its pronounced autonomic activation (e.g. tachycardia and palpitations) panic disorder (PD) has long been investigated with regard to possible cardiac dysregulation (Friedman, 2007). It has been established that patients who suffer from PD have an altered pattern of cardiac control, characterised by reduced heart rate variability (HRV; Cohen et al., 2000; Klein et al., 1995; Middleton et al., 1994; Yeragani et al., 1990, 1993). The HRV of patients with PD is reduced in both panicogenic as well as in resting conditions, which indicates that PD is associated with abnormal cardiac control in both tonic and phasic states (Friedman, 2007).

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