Brief reportNorepinephrine infusions in congestive heart failure
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Cited by (22)
Carvedilol increases blood pressure response to phenylephrine infusion in heart failure subjects with systolic dysfunction: Evidence of improved vascular α<inf>1</inf>-adrenoreceptor signal transduction
2008, American Heart JournalCitation Excerpt :This increased BP response was evident despite sustained reductions in preinfusion BP, suggesting a previously undescribed pharmacologic consequence of carvedilol in subjects with HF: the potential up-regulation of impaired vascular α1-AR signal transduction in human HF. Goldsmith et al24 first reported evidence for desensitization of vascular α1-ARs in subjects with HF. In this study, supraphysiologic doses of norepinephrine failed to elicit a BP or HR response, suggesting some defect or impairment of the α1-AR signaling pathway in patients with HF.
Changes in myocardial and vascular receptors in heart failure
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