Altered myocardial high-energy phosphate metabolites in patients with dilated cardiomyopathy

https://doi.org/10.1016/0002-8703(91)90527-OGet rights and content

Abstract

Myocardial high-energy phosphate metabolism in patients with dilated cardiomyopathy (DCM) of ischemic or idiopathic etiology was assessed at rest by one-dimensional phase-encoded 31P-nuclear magnetic resonance (NMR) spectroscopy studies performed in conjunction with 1H imaging in 20 patients with DCM and in 12 normal volunteers. The messured values of anterior myocardial phosphocreatine/β-adenosine triphosphate (PCrβ-ATP), corrected for partial saturation and contamination of the spectra by blood metabolites, averaged 1.80 ± 0.06 (mean ± SE) in normal volunteers and 1.46 ± 0.07 in the patients overall, a highly significant (p < 0.001) decrease. In patients with DCM accompanied by coronary artery disease (n = 9), the PCrβ-ATP ratio averaged 1.53 ± 0.07, while in those with DCM alone it was 1.41 ± 0.12 (n = 11), a value that was not significantly different. There was no significant correlation (r = 0.34) between myocardial PCrATP ratio and left ventricular ejection fraction in patients. These studies demonstrate that myocardial PCrATP ratios are reduced at rest in human ischemic and idiopathic dilated cardiomyopathy.

References (27)

  • JL Swain et al.

    Derangements in myocardial purine and pyrimidine nucleotide metabolism in patients with coronary artery disease and left ventricular hypertrophy

  • PA Bottomley

    Non-invasive study of high-energy phosphate metabolism in human heart by depth-resolved 31P NMR spectroscopy

    Science

    (1985)
  • MJ Blackledge et al.

    Quantitative studies of human cardiac metabolism by P-31 rotating-frame NMR

  • Cited by (214)

    • Latest Updates in Heart Failure Imaging

      2023, Heart Failure Clinics
    • Evaluating tissue bioenergetics by phosphorous-31 magnetic resonance spectroscopy

      2020, Clinical Bioenergetics: From Pathophysiology to Clinical Translation
    View all citing articles on Scopus
    View full text