Skip to main content

Advertisement

SpringerLink
Log in

Differential Diagnosis of Parkinsonism Using Dual-Phase F-18 FP-CIT PET Imaging

  • Original Article
  • Published:
Nuclear Medicine and Molecular Imaging Aims and scope Submit manuscript

Abstract

Purpose

Dopamine transporter (DAT) imaging can demonstrate presynaptic dopaminergic neuronal loss in Parkinson’s disease (PD). However, differentiating atypical parkinsonism (APD) from PD is often difficult. We investigated the usefulness of dual-phase F-18 FP-CIT positron emission tomography (PET) imaging in the differential diagnosis of parkinsonism.

Methods

Ninety-eight subjects [five normal, seven drug-induced parkinsonism (DIP), five essential tremor (ET), 24 PD, 20 multiple system atrophy-parkinson type (MSA-P), 13 multiple system atrophy-cerebellar type (MSA-C), 13 progressive supranuclear palsy (PSP), and 11 dementia with Lewy bodies (DLB)] underwent F-18 FP-CIT PET. PET images were acquired at 5 min (early phase) and 3 h (late phase) after F-18 FP-CIT administration (185 MBq). Regional uptake pattern of cerebral and cerebellar hemispheres was assessed on early phase images and striatal DAT binding pattern was assessed on late phase images, using visual, quantitative, and statistical parametric mapping (SPM) analyses.

Results

Striatal DAT binding was normal in normal, ET, DIP, and MSA-C groups, but abnormal in PD, MSA-P, PSP, and DLB groups. No difference was found in regional uptake on early phase images among normal DAT binding groups, except in the MSA-C group. Abnormal DAT binding groups showed different regional uptake pattern on early phase images compared with PD in SPM analysis (FDR < 0.05). When discriminating APD from PD, visual interpretation of the early phase image showed high diagnostic sensitivity and specificity (75.4 % and 100 %, respectively). Regarding the ability to distinguish specific APD, sensitivities were 81 % for MSA-P, 77 % for MSA-C, 23 % for PSP, and 54.5 % for DLB.

Conclusions

Dual-phase F-18 FP-CIT PET imaging is useful in demonstrating striatal DAT loss in neurodegenerative parkinsonism, and also in differentiating APD, particularly MSA, from PD.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  1. Hughes AJ, Daniel SE, Lees AJ. The clinical features of Parkinson’s disease in 100 histologically proven cases. Adv Neurol. 1993;60:595–9.

    PubMed  CAS  Google Scholar 

  2. Rajput AH, Offord KP, Beard CM, Kurland LT. Epidemiology of parkinsonism: incidence, classification, and mortality. Ann Neurol. 1984;16:278–82.

    Article  PubMed  CAS  Google Scholar 

  3. Bower JH, Dickson DW, Taylor L, Maraganore DM, Rocca WA. Clinical correlates of the pathology underlying parkinsonism: a population perspective. Mov Disord. 2002;17:910–6.

    Article  PubMed  Google Scholar 

  4. Litvan I, Agid Y, Jankovic J, Goetz C, Brandel JP, Lai EC, et al. Accuracy of clinical criteria for the diagnosis of progressive supranuclear palsy (Steele-Richardson-Olszewski syndrome). Neurology. 1996;46:922–30.

    Article  PubMed  CAS  Google Scholar 

  5. Seppi K, Yekhlef F, Diem A, Luginger Wolf E, Mueller J, Tison F, et al. Progression of parkinsonism in multiple system atrophy. J Neurol. 2005;252:91–6.

    Article  PubMed  Google Scholar 

  6. Poewe W, Wenning G. The differential diagnosis of Parkinson’s disease. Eur J Neurol. 2002;9 Suppl 3:23–30.

    Article  PubMed  Google Scholar 

  7. Litvan I, Bhatia KP, Burn DJ, Goetz CG, Lang AE, McKeith I, et al. Movement Disorders Society Scientific Issues Committee report: SIC Task Force appraisal of clinical diagnostic criteria for Parkinsonian disorders. Mov Disord. 2003;18:467–86.

    Article  PubMed  Google Scholar 

  8. Barclay CL, Lang AE. Dystonia in progressive supranuclear palsy. J Neurol Neurosurg Psychiatry. 1997;62:352–6.

    Article  PubMed  CAS  Google Scholar 

  9. Wenning GK, Tison F, Ben Shlomo Y, Daniel SE, Quinn NP. Multiple system atrophy: a review of 203 pathologically proven cases. Mov Disord. 1997;12:133–47.

    Article  PubMed  CAS  Google Scholar 

  10. Bensimon G, Ludolph A, Agid Y, Vidailhet M, Payan C, Leigh PN. Riluzole treatment, survival and diagnostic criteria in Parkinson plus disorders: the NNIPPS study. Brain. 2009;132(Pt 1):156–71.

    PubMed  Google Scholar 

  11. Juh R, Kim J, Moon D, Choe B, Suh T. Different metabolic patterns analysis of Parkinsonism on the 18 F-FDG PET. Eur J Radiol. 2004;51:223–33.

    Article  PubMed  Google Scholar 

  12. Van Laere K, Casteels C, De Ceuninck L, Vanbilloen B, Maes A, Mortelmans L, et al. Dual-tracer dopamine transporter and perfusion SPECT in differential diagnosis of parkinsonism using template-based discriminant analysis. J Nucl Med. 2006;47:384–92.

    PubMed  Google Scholar 

  13. Schocke MF, Seppi K, Esterhammer R, Kremser C, Jaschke W, Poewe W, et al. Diffusion-weighted MRI differentiates the Parkinson variant of multiple system atrophy from PD. Neurology. 2002;58:575–80.

    Article  PubMed  CAS  Google Scholar 

  14. Brooks DJ. Imaging approaches to Parkinson disease. J Nucl Med. 2010;51:596–609.

    Article  PubMed  CAS  Google Scholar 

  15. Pirker W, Asenbaum S, Bencsits G, Prayer D, Gerschlager W, Deecke L, et al. [123I]beta-CIT SPECT in multiple system atrophy, progressive supranuclear palsy, and corticobasal degeneration. Mov Disord. 2000;15:1158–67.

    Article  PubMed  CAS  Google Scholar 

  16. Varrone A, Marek KL, Jennings D, Innis RB, Seibyl JP. [(123)I]beta-CIT SPECT imaging demonstrates reduced density of striatal dopamine transporters in Parkinson’s disease and multiple system atrophy. Mov Disord. 2001;16:1023–32.

    Article  PubMed  CAS  Google Scholar 

  17. Kazumata K, Dhawan V, Chaly T, Antonini A, Margouleff C, Belakhlef A, et al. Dopamine transporter imaging with fluorine-18-FPCIT and PET. J Nucl Med. 1998;39:1521–30.

    PubMed  CAS  Google Scholar 

  18. Kim JS. Practical Approach for the Clinal Use of Dopamine Transporter Imaging. Nucl Med Mol Imaging. 2008;42(6):425–34.

    Google Scholar 

  19. Maqsood Y, Ronald B, van Berckel BNM, Ponsen MM, Mark L, Windhorst AD, et al. Quantification of dopamine transporter binding using [18 F]FP-β-CIT and positron emmision tomography. J Cereb Blood Flow & Metabol. 2007;27:1397–406.

    Article  Google Scholar 

  20. Kim JS. Quantitative analysis and reproducibility of dopamine transporter density using [18 F]FPCIT positron emission tomography. Ph.D. Thesis, Seoul National University, February 2006.

  21. Sokoloff L. Relationships among local functional activity, energy metabolism, and blood flow in the central nervous system. Fed Proc. 1981;40:2311–6.

    PubMed  CAS  Google Scholar 

  22. Hughes AJ, Daniel SE, Kilford L, Lees AJ. Accuracy of clinical diagnosis of Idiopathic Parkinson’s disease: a clinico-pathological study of 100 cases. J Neurol Nerosurg Psychiatry. 1992;55(3):181–4.

    Article  CAS  Google Scholar 

  23. Gilman S, Wenning GK, Low PA, Brooks DJ, Mathias CJ, Trojanowski JQ, et al. Second consensus statement on the diagnosis of multiple system atrophy. Neurology. 2008;71:670–6.

    Article  PubMed  CAS  Google Scholar 

  24. Litvan I, MacIntyre A, Goetz CG, Wenning GK, Jellinger K, Verny M, et al. Accuracy of the clinical diagnoses of Lewy body disease, Parkinson disease, and dementia with Lewy bodies: a clinicopathologic study. Arch Neurol. 1998;55:969–78.

    Article  PubMed  CAS  Google Scholar 

  25. Lee SJ, Oh SJ, Chi DY, Kang SH, Kil HS, Kim JS, et al. One-step high-radiochemical-yield synthesis of [18 F]FP-CIT using a protic solvent system. Nucl Med Biol. 2007;34:345–51.

    Article  PubMed  CAS  Google Scholar 

  26. Kwon KY, Choi CG, Kim JS, Lee MC, Chung SJ. Comparison of brain MRI and 18 F-FDG PET in the differential diagnosis of multiple system atrophy from Parkinson’s disease. Mov Disord. 2007;22:2352–8.

    Article  PubMed  Google Scholar 

  27. Kasanuki K, Iseki E, Fujishiro H, Yamamoto R, Higashi S, Minegishi M, et al. Neuropathological investigation of the hypometabolic regions on positron emission tomography with [(18)F] fluorodeoxyglucose in patients with dementia with Lewy bodies. J Neurol Sci. 2012;314:111–9.

    Article  PubMed  CAS  Google Scholar 

  28. Kimura N, Hanaki S, Masuda T, Hanaoka T, Hazama Y, Okazaki T, et al. Brain perfusion differences in Parkinsonian disorders. Mov Disord. 2011;26(14):2530–7.

    Article  PubMed  Google Scholar 

  29. Sun FT, Schriber RA, Greenia JM, He J, Gitcho A, Jagust WJ. Automated template-based PET region of interest analyses in the aging brain. NeuroImage. 2007;34:608–17.

    Article  PubMed  Google Scholar 

  30. Oh SW, Kim YK, Lee BC, Kim BS, Kim JS, Kim JM, et al. Evaluation of Multiple System Atrophy and Early Parkinson’s Disease Using 123I-FP-CIT SPECT. Nucl Med Mol Imaging. 2009;43:10–8.

    Google Scholar 

  31. Kim BS, Jang SJ, Eo JS, Park EK, Kim YK, Kim JM, et al. The Discriminating Nature of Dopamine Transporter Image in Parkinsonism: The Competency of Dopaminergic Transporter Imaging in Differential Diagnosis Of Parkinsonism: 123I-FP-CIT SPECT Study. Nucl Med Mol Imaging. 2007;41:272–9.

    Google Scholar 

  32. Morrish PK, Sawle GV, Brooks DJ. Clinical and [18 F] dopa PET findings in early Parkinson’s disease. J Neurol Neurosurg Psychiatry. 1995;59:597–600.

    Article  PubMed  CAS  Google Scholar 

  33. Marek K, Innis R, van Dyck C, Fussell B, Early M, Eberly S, et al. [123I]beta-CIT SPECT imaging assessment of the rate of Parkinson’s disease progression. Neurology. 2001;57:2089–94.

    Article  PubMed  CAS  Google Scholar 

  34. Antonini A, Benti R, De Notaris R, Tesei S, Zecchinelli A, Sacilotto G, et al. 123I-Ioflupane/SPECT binding to striatal dopamine transporter (DAT) uptake in patients with Parkinson’s disease, multiple system atrophy, and progressive supranuclear palsy. Neurol Sci. 2003;24:149–50.

    Article  PubMed  CAS  Google Scholar 

  35. Eidelberg D, Moeller JR, Dhawan V, Spetsieris P, Takikawa S, Ishikawa T, et al. The metabolic topography of parkinsonism. J Cereb Blood Flow Metab. 1994;14:783–801.

    Article  PubMed  CAS  Google Scholar 

  36. Brooks DJ. Functional imaging in relation to parkinsonian syndromes. J Neurol Sci. 1993;115:1–17.

    Article  PubMed  CAS  Google Scholar 

  37. Eckert T, Barnes A, Dhawan V, Frucht S, Gordon MF, Feigin AS, et al. FDG PET in the differential diagnosis of parkinsonian disorders. NeuroImage. 2005;26:912–21.

    Article  PubMed  Google Scholar 

  38. Bosman T, Van Laere K, Santens P. Anatomically standardised 99mTc-ECD brain perfusion SPET allows accurate differentiation between healthy volunteers, multiple system atrophy and idiopathic Parkinson’s disease. Eur J Nucl Med Mol Imaging. 2003;30:16–24.

    Article  PubMed  CAS  Google Scholar 

  39. Wong CY, Thie J, Gaskill M, Ponto R, Hill J, Tian HY, et al. A statistical investigation of normal regional intra-subject heterogeneity of brain metabolism and perfusion by F-18 FDG and O-15 H2O PET imaging. BMC Nucl Med. 2006;6:4.

    Article  PubMed  Google Scholar 

  40. Meyer PT, Hellwig S, Amtage F, Rottenburger C, Sahm U, Reuland P, et al. Dual-biomarker imaging of regional cerebral amyloid load and neuronal activity in dementia with PET and 11C-labeled Pittsburgh compound B. J Nucl Med. 2011;52:393–400.

    Article  PubMed  Google Scholar 

  41. Litvan I, Goetz CG, Jankovic J, Wenning GK, Booth V, Bartko JJ, et al. What is the accuracy of the clinical diagnosis of multiple system atrophy? A clinicopathologic study. Arch Neurol. 1997;54:937–44.

    Article  PubMed  CAS  Google Scholar 

Download references

Conflicts of Interest

The authors declare no conflict of interest

Author information

Authors and Affiliations

  1. Department of Nuclear Medicine, Asan Medical Center, College of Medicine, University of Ulsan, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 138-736, South Korea

    Soyoung Jin, Minyoung Oh, Seung Jun Oh, Jungsu S. Oh, Sang Ju Lee & Jae Seung Kim

  2. Department of Neurology, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, South Korea

    Sun Ju Chung & Chong Sik Lee

Authors
  1. Soyoung Jin
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Minyoung Oh
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Seung Jun Oh
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Jungsu S. Oh
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Sang Ju Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Sun Ju Chung
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Chong Sik Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Jae Seung Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Jae Seung Kim.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Jin, S., Oh, M., Oh, S.J. et al. Differential Diagnosis of Parkinsonism Using Dual-Phase F-18 FP-CIT PET Imaging. Nucl Med Mol Imaging 47, 44–51 (2013). https://doi.org/10.1007/s13139-012-0182-4

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13139-012-0182-4

Keywords

Search

Navigation