Abstract
Noninvasive imaging in living subjects with positron emission tomography (PET) provides early detection of diseases in humans. For this application, it is necessary to prepare specific molecular imaging probes labeled with positron-emitting radioisotopes such as fluorine-18 for obtaining high-quality PET imaging. In this review, we describe recent trends in the F-18 radiolabeling method for the introduction of no-carrier-added fluorine-18, which was obtained from an 18O(p,n)18F reaction, into a specific molecular site, which in turn is intended to serve as an imaging agent for PET study. These labeling protocols are based on ionic liquid media 18F radiofluorination in the presence of some water, enzymatic 18F fluorination using fluorinase in water solution, non-polar protic alcohol media 18F radiofluorination and its mechanism, and nucleophilic 18F fluorination of an aromatic iodonium salt precursor.
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Acknowledgment
This work was supported by Nuclear Research and Development Program of the Korea Science and Engineering Foundation (KOSEF) grant funded by the Korean government (MEST) (grant code: 2009-0078422 and 2009-0062472 to D.W.K). We also thank Dr. Vinod H. Jadhav for helpful discussions.
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Kim, D.W., Jeong, HJ., Lim, S.T. et al. Recent Trends in the Nucleophilic [18F]-radiolabeling Method with No-carrier-added [18F]fluoride. Nucl Med Mol Imaging 44, 25–32 (2010). https://doi.org/10.1007/s13139-009-0008-1
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DOI: https://doi.org/10.1007/s13139-009-0008-1