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Emerging Molecular Targets for Intravascular Imaging of High-Risk Plaques

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Abstract

Accumulating evidence links catastrophic cardiovascular events to the inflammatory, angiogenic, and apoptotic biological profiles underlying high-risk atherosclerotic plaques. While biological detail is opaque to traditional anatomical imaging readouts, emerging molecular imaging approaches are now yielding significant clinical insights into the biological diagnosis, characterization, and treatment of atherosclerotic vascular disease. Yet, while clinical molecular imaging approaches are available for larger arterial beds such as the carotid arteries or aorta, molecular imaging pathways for human coronary arterial plaques are lacking. Excitingly, the recent advent of intravascular near-infrared fluorescence technology now offers new potential for in vivo molecular imaging of key molecular and cellular targets in coronary-sized vasculature. Here we provide a framework for coronary artery–targeted molecular imaging using intravascular imaging technology, and present key molecular imaging targets relevant to the detection of high-risk, vulnerable coronary plaques.

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Acknowledgments

Supported by the American Heart Association Scientist Development Grant (#0830352N to FAJ) and Howard Hughes Medical Institute Early Career Award (FAJ), and the CardioVascular Research Foundation (CVRF) (JWK).

Disclosure

Dr. Jaffer is a consultant for and has equity interest in VisEn Medical.

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Authors and Affiliations

  1. Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA

    Jin Won Kim

  2. Cardiovascular Center, Korea University, Guro Hospital, Seoul, Republic of Korea

    Jin Won Kim

  3. Cardiovascular Research Center, Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, MGH CVRC, Simches Research Building, Room 3206, 185 Cambridge Street, Boston, MA, 02114-2790, USA

    Farouc A. Jaffer

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  1. Jin Won Kim
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Correspondence to Farouc A. Jaffer.

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Kim, J.W., Jaffer, F.A. Emerging Molecular Targets for Intravascular Imaging of High-Risk Plaques. curr cardiovasc imaging rep 3, 237–247 (2010). https://doi.org/10.1007/s12410-010-9028-6

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