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Direct comparison of radiation dosimetry of six PET tracers using human whole-body imaging and murine biodistribution studies

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Abstract

Objective

We investigated the whole-body biodistributions and radiation dosimetry of five 11C-labeled and one 18F-labeled radiotracers in human subjects, and compared the results to those obtained from murine biodistribution studies.

Methods

The radiotracers investigated were 11C-SA4503, 11C-MPDX, 11C-TMSX, 11C-CHIBA-1001, 11C-4DST, and 18F-FBPA. Dynamic whole-body positron emission tomography (PET) was performed in three human subjects after a single bolus injection of each radiotracer. Emission scans were collected in two-dimensional mode in five bed positions. Regions of interest were placed over organs identified in reconstructed PET images. The OLINDA program was used to estimate radiation doses from the number of disintegrations of these source organs. These results were compared with the predicted human radiation doses on the basis of biodistribution data obtained from mice by dissection.

Results

The ratios of estimated effective doses from the human-derived data to those from the mouse-derived data ranged from 0.86 to 1.88. The critical organs that received the highest absorbed doses in the human- and mouse-derived studies differed for two of the six radiotracers. The differences between the human- and mouse-derived dosimetry involved not only the species differences, including faster systemic circulation of mice and differences in the metabolism, but also measurement methodologies.

Conclusions

Although the mouse-derived effective doses were roughly comparable to the human-derived doses in most cases, considerable differences were found for critical organ dose estimates and pharmacokinetics in certain cases. Whole-body imaging for investigation of radiation dosimetry is desirable for the initial clinical evaluation of new PET probes prior to their application in subsequent clinical investigations.

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Acknowledgments

This work was supported by Grants-in-Aid for Scientific Research (C) No. 19591665 (Tadashi Nariai), (B) No. 22390241 (Jun Toyohara), and (B) No. 20390334 (Kiichi Ishiwata) from the Japan Society for the Promotion of Science, and a Grant from the National Center for Global Health and Medicine (Jun Toyohara, Tadashi Nariai, and Kiichi Ishiwata).

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Authors and Affiliations

  1. Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, 1-1 Naka-cho, Itabashi-ku, Tokyo, 173-0022, Japan

    Muneyuki Sakata, Keiichi Oda, Jun Toyohara, Kenji Ishii, Tadashi Nariai & Kiichi Ishiwata

  2. Department of Neurosurgery, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan

    Tadashi Nariai

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  1. Muneyuki Sakata
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  2. Keiichi Oda
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  3. Jun Toyohara
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  4. Kenji Ishii
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  5. Tadashi Nariai
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Correspondence to Muneyuki Sakata.

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Sakata, M., Oda, K., Toyohara, J. et al. Direct comparison of radiation dosimetry of six PET tracers using human whole-body imaging and murine biodistribution studies. Ann Nucl Med 27, 285–296 (2013). https://doi.org/10.1007/s12149-013-0685-9

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  • DOI: https://doi.org/10.1007/s12149-013-0685-9

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