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Role of F-18 FDG PET/CT in assessing bone marrow involvement in pediatric Hodgkin’s lymphoma

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Abstract

Objectives

The aim of the current study was to assess the utility of F-18-fluoro-2-deoxy-d-glucose (F-18 FDG) positron emission tomography/computed tomography (PET/CT) in assessing bone marrow involvement (BMI) compared to bone marrow biopsy (BMB) in initial staging of Hodgkin’s lymphoma (HL) in pediatric patients.

Methods

Data of 38 pediatric patients (mean age 9.8 years, range 3–18 years) with HL were analyzed for the involvement of bone marrow. All patients underwent non-contrast F-18 FDG PET/CT study. BMB was done in 31 patients from the bilateral iliac crests. Scans were interpreted by two nuclear medicine physicians blinded to the details of BMB.

Results

Of the 31 patients who underwent BMB, 5 patients had lymphomatous involvement on BMB. PET/CT was positive in four of these five patients. In 26 patients negative on BMB, PET was negative in 23 patients and positive in 3 patients for BMI. The sensitivity and negative predictive value of F-18 FDG PET/CT was 87.5 and 96 %, respectively, for BMI.

Conclusions

F-18 FDG PET/CT can predict BMB results with high accuracy. F-18 FDG PET/CT may be used at initial staging of pediatric Hodgkin’s lymphoma as it uncovers unsuspected BMI and BMB may be omitted in patients with PET-positive BMI.

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Authors and Affiliations

  1. Department of Nuclear Medicine and PET, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India

    Kanhaiyalal Agrawal, Bhagwant Rai Mittal, Kuruva Manohar, Raghava Kashyap & Anish Bhattacharya

  2. Pediatric Hematology/Oncology Unit, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India

    Deepak Bansal, Amita Trehan & Ram K. Marwaha

  3. Department of Hematology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India

    Neelam Varma

  4. Department of Cytology and Gynaecological Pathology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India

    Radhika Srinivasan

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  1. Kanhaiyalal Agrawal
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  2. Bhagwant Rai Mittal
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  3. Deepak Bansal
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Correspondence to Bhagwant Rai Mittal.

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Agrawal, K., Mittal, B.R., Bansal, D. et al. Role of F-18 FDG PET/CT in assessing bone marrow involvement in pediatric Hodgkin’s lymphoma. Ann Nucl Med 27, 146–151 (2013). https://doi.org/10.1007/s12149-012-0665-5

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  • DOI: https://doi.org/10.1007/s12149-012-0665-5

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