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Radiation exposure and risk–benefit analysis in cancer screening using FDG-PET: results of a Japanese nationwide survey

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Abstract

Objective

The aim of this study was to estimate radiation exposure and evaluate the risks and benefits of 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) in cancer screening.

Methods

A nationwide survey of FDG-PET cancer screening was conducted in 2006, and the results were analyzed with a common index, “extension/shortening of the average life expectancy.”

Results

The average estimated effective dose was 4.4 mSv (male 4.7 mSv; female 4.0 mSv) for dedicated PET and 13.5 mSv (male 14.2 mSv; female 12.8 mSv) for PET/computed tomography (CT). The risk–benefit break-even age from the viewpoint of radiation exposure was in the 40s for men and 30s for women for dedicated PET and in the 50s for men and 50s (variable injection dose) or 60s (constant injection dose) for women for PET/CT.

Conclusions

FDG-PET cancer screening is beneficial for examinees above the break-even ages. The risks and benefits should be explained to examinees because of the larger radiation used in cancer FDG-PET screening compared with other X-ray tests.

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Acknowledgments

This research was supported by a Grant-in-Aid for Cancer Research from the Ministry of Health, Labor, and Welfare, Japan. The authors thank Sachiko Yanagida and Yoshihide Nakamura of the Japan Radioisotope Association for their cooperation in the field investigation.

Author information

Authors and Affiliations

  1. Division of Cancer Screening, Research Center for Cancer Prevention and Screening, National Cancer Center, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan

    Takeshi Murano & Takashi Terauchi

  2. Department of Radiology, Yokohama City University Graduate School of Medicine, Kanagawa, Japan

    Takeshi Murano & Tomio Inoue

  3. Division of Nuclear Medicine, Department of Radiology, National Center for Global Health and Medicine, Tokyo, Japan

    Ryogo Minamimoto

  4. Division of Molecular Imaging, Institute of Biomedical Research and Innovation, Hyogo, Japan

    Michio Senda

  5. Nishidai Clinic, Tokyo, Japan

    Kimiichi Uno

  6. Atsuchi Memorial Institute of Radiology, Atsuchi Memorial Clinic PET Center, Kagoshima, Japan

    Seishi Jinnouchi

  7. Department of Nuclear Medicine and Radiology, Institute of Development, Aging and Cancer, Tohoku University, Miyagi, Japan

    Hiroshi Fukuda

  8. National Institute of Radiological Sciences, Chiba, Japan

    Takeshi Iinuma

  9. Medical Cooperation Teishinkai Central CI Clinic, Hokkaido, Japan

    Eriko Tsukamoto

  10. Koga Hospital 21 PET Center, Fukuoka, Japan

    Tsuyoshi Yoshida

  11. Center for Advanced Information Science and Technology, The University of Aizu, Fukushima, Japan

    Shinya Oku

  12. Hamamatsu Medical Imaging Center, Hamamatsu Medical Photonics Foundation, Shizuoka, Japan

    Sadahiko Nishizawa

  13. Center for Development of Advanced Medicine for Dementia, National Center for Geriatrics and Gerontology, Aichi, Japan

    Kengo Ito

  14. Positron Imaging Center, Aizawa Hospital, Nagano, Japan

    Kazuhiro Oguchi

  15. Yuai Clinic, Diagnostic Imaging Center, Radiology, Kanagawa, Japan

    Masami Kawamoto

  16. Japanese Red Cross Kumamoto Health Care Center, Kumamoto, Japan

    Rumi Nakashima

  17. Nagoya Radiological Diagnosis Foundation, Aichi, Japan

    Hiroshi Iwata

Authors
  1. Takeshi Murano
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  2. Ryogo Minamimoto
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  3. Michio Senda
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  4. Kimiichi Uno
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  5. Seishi Jinnouchi
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  6. Hiroshi Fukuda
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  7. Takeshi Iinuma
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  8. Eriko Tsukamoto
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  9. Takashi Terauchi
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  10. Tsuyoshi Yoshida
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  11. Shinya Oku
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  12. Sadahiko Nishizawa
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  13. Kengo Ito
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  14. Kazuhiro Oguchi
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  15. Masami Kawamoto
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  16. Rumi Nakashima
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  17. Hiroshi Iwata
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  18. Tomio Inoue
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Corresponding author

Correspondence to Takeshi Murano.

Additional information

This article was previously published in Kakuigaku in Japanese (48[1]:1–13.2011). We obtained permission from the editorial office to republish this article in English.

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Murano, T., Minamimoto, R., Senda, M. et al. Radiation exposure and risk–benefit analysis in cancer screening using FDG-PET: results of a Japanese nationwide survey. Ann Nucl Med 25, 657–666 (2011). https://doi.org/10.1007/s12149-011-0511-1

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  • DOI: https://doi.org/10.1007/s12149-011-0511-1

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