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18F-FAMT uptake correlates with tumor proliferative activity in oral squamous cell carcinoma: comparative study with 18F-FDG PET and immunohistochemistry

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Abstract

Objective

l-3-[18F]-fluoro-α-methyl tyrosine (FAMT) is transported into cancer cells by l-type amino acid transporter 1 (LAT1). The purpose of the present study is to correlate the uptake of FAMT and FDG with the cellular proliferative activity measured by the Ki-67 labeling index (Ki-67 LI) in oral squamous cell carcinoma (OSCC).

Methods

Twenty-five patients with OSCC were enrolled in this study. Both FAMT-PET and FDG-PET were performed within 4 weeks before surgery in all cases. The uptake of FAMT and FDG was compared by semiquantitative analysis with maximal standardized uptake values (SUVmax) of the primary tumors. Ki-67 LI of the tumors was analyzed by immunohistochemical staining and correlated with the clinicopathologic variables and the uptake of PET tracers.

Results

For primary tumor detection, FAMT-PET exhibited a sensitivity of 84%, whereas that of FDG-PET was 88%. In all visible lesions, mean FDG uptake determined by average SUVmax was 9.7 (range 4.2–15.9) and mean FAMT uptake was 3.5 (range 1.3–8.5). The SUVmax of FAMT tended to show a better correlation with Ki-67 LI (r = 0.878) than that of FDG (r = 0.643).

Conclusions

Uptake of FAMT correlated with cellular proliferation of OSCC. FAMT-PET may be a useful procedure to evaluate tumor proliferation of OSCC.

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Acknowledgments

This work was supported by grants from the Japan Society for the Promotion of Science (21st Century COE Program-Gunma University). We also thank Dr. Toru Yamaguchi and Ms. Mayumi Tomaru for helpful suggestions with respect to immunohistochemistry.

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Authors and Affiliations

  1. Department of Stomatology and Oral Surgery, Gunma University Graduate School of Medicine, Maebashi, Japan

    Go Miyashita, Mitsuyuki Miyakubo, Tomohiro Ishikita, Yoshiki Nakasone, Akihide Negishi & Satoshi Yokoo

  2. Department of Diagnostic Radiology and Nuclear Medicine, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma, 371-8511, Japan

    Tetsuya Higuchi, Noboru Oriuchi, Yukiko Arisaka & Keigo Endo

  3. Department of Bioimaging Information Analysis, Gunma University Graduate School of Medicine, Maebashi, Japan

    Hirofumi Hanaoka

  4. Department of Molecular Imaging, Gunma University Graduate School of Medicine, Maebashi, Japan

    Hideyuki Tominaga

  5. Department of Clinical Statistics and Epidemiology, Yokohama City University Medical Center, Yokohama, Japan

    Satoshi Morita

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  1. Go Miyashita
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  2. Tetsuya Higuchi
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  3. Noboru Oriuchi
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  6. Hideyuki Tominaga
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  7. Satoshi Morita
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  8. Mitsuyuki Miyakubo
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  9. Tomohiro Ishikita
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  10. Yoshiki Nakasone
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  11. Akihide Negishi
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  13. Keigo Endo
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Corresponding author

Correspondence to Noboru Oriuchi.

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Miyashita, G., Higuchi, T., Oriuchi, N. et al. 18F-FAMT uptake correlates with tumor proliferative activity in oral squamous cell carcinoma: comparative study with 18F-FDG PET and immunohistochemistry. Ann Nucl Med 24, 579–584 (2010). https://doi.org/10.1007/s12149-010-0398-2

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  • DOI: https://doi.org/10.1007/s12149-010-0398-2

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