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Generation of planar images from lung ventilation/perfusion SPECT

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Abstract

Objective

To develop a method of producing lung ventilation and perfusion (V/Q) planar images using forward projection of reconstructed single-photon emission computed tomography (SPECT) images through approximate attenuation (µ) maps generated from the lung emission scans alone, as transmission-based µ maps may not be routinely available.

Methods

Synthetic µ maps are derived from 99mTc photopeak and “scatter” windows for the attenuation correction of the SPECT images. The attenuation-corrected SPECT images are forward projected at appropriate angles to give the equivalent of planar images. This method allows high-count planar images, as well as the SPECT images, to be produced from a single SPECT acquisition. In addition, isolated “single lung” views of lateral and medial projections without “shine-through” from the contra-lateral lung, which have not been available previously, can be formed.

Results

Comparison of reprojected images produced from CT-derived or synthetic µ maps displayed similar detail and radiopharmaceutical distribution. In a blinded comparison of “true” planar images with those from reprojecting the SPECT data using the synthetic µ maps, no difference in mismatched defect detection was found, and hence it was confirmed that the reprojected planar images could replace true planar images with no loss in planar diagnostic sensitivity.

Conclusions

The reprojected planar images provide high-count, high-quality images, which are comparable with conventional 2D images.

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References

  1. Schuemichen C. Pulmonary embolism: is multislice CT the method of choice? (Against). Eur J Nucl Med Mol Imaging 2005;32:107–112.

    Article  PubMed  Google Scholar 

  2. Stein PD, Woodard PK, Weg JG, Wakefield TW, Tapson VF, Sostman HD, et al. Diagnostic pathways in acute pulmonary embolism: recommendations of the PIOPED II investigators. Am J Med 2006;119:1048–1055.

    Article  PubMed  Google Scholar 

  3. Maki D, Gefter W, Alavi A. Recent advances in pulmonary imaging. Chest 1999;5:1388–1402.

    Article  Google Scholar 

  4. PIOPED. Value of the ventilation/perfusion scan in acute pulmonary embolism: results of the prospective investigation of pulmonary embolism diagnosis (PIOPED). JAMA 1990;263:2753–2759.

    Article  Google Scholar 

  5. Gottschalk A, Stein PD, Sostman HD, Matta F, Beemath A. Very low probability interpretation of V/Q lung scans in combination with low probability objective clinical assessment reliably excludes pulmonary embolism: data from PIOPED II. J Nucl Med 2007;48:1411–1415.

    Article  PubMed  Google Scholar 

  6. Reinartz P, Wildberger JE, Schaefer W, Nowak B, Mahnken AH, Buell U. Tomographic imaging in the diagnosis of pulmonary embolism: a comparison between V/Q lung scintigraphy in SPECT technique and multislice spiral CT. J Nucl Med 2004;45:1501–1508.

    PubMed  Google Scholar 

  7. Reinartz P, Schirp U, Zimmy M, Sabri O, Nowak B, Schaefer W, et al. Optimizing ventilation-perfusion lung scintigraphy: parting with planar imaging. Nuklearmedizin 2001;40:38–43.

    PubMed  CAS  Google Scholar 

  8. Pan TS, King MA, Luo DS, Dahlberg ST, Villegas BJ. Estimation of attenuation maps from scatter and photopeak window single photon-emission computed tomographic images of technetium 99m-labeled sestamibi. J Nucl Cardiol 1997;4(1 Pt 1):42–51.

    Article  PubMed  CAS  Google Scholar 

  9. Roach P, Bailey D, Cooper R, Schembri G, HoShon I, Bautovich G, et al. Clinical assessment of planar-like images generated from V-Q SPECT scans (abstract). J Nucl Med 2005;46Suppl 1:336P.

    Google Scholar 

  10. Hudson HM, Larkin RS. Accelerated image reconstruction using ordered subsets of projection data. IEEE Trans Med Imaging 1994;13:601–609.

    Article  PubMed  CAS  Google Scholar 

  11. Palmer J, Bitzen U, Jonson B, Bajc M. Comprehensive ventilation/perfusion SPECT. J Nucl Med 2001;42:1288–1294.

    PubMed  CAS  Google Scholar 

  12. Harris B, Bailey DL, Miles S, Bailey EA, Rogers K, Roach PJ, et al. Objective analysis of tomographic ventilation perfusion scintigraphy in pulmonary embolism. Am J Respir Crit Care Med 2007;175:1173–1180.

    Article  PubMed  Google Scholar 

  13. Gustafsson A, Bake B, Jacobsson L, Johansson A, Ljungberg M, Moonen M. Evaluation of attenuation corrections using Monte Carlo simulated lung SPECT. Phys Med Biol 1998;43:2325–2336.

    Article  PubMed  CAS  Google Scholar 

  14. Bailey DL, Roach PJ, Bailey EA, Hewlett J, Keijzers R. Development of a modular cost-effective SPECT/CT scanner. Eur J Nucl Med Mol Imaging 2007;34:1415–1426.

    Article  PubMed  Google Scholar 

  15. Brown S, Bailey DL, Baldock CA. Relationship between CT Hounsfield units and linear attenuation coefficients for a number of single photon-emitting radionuclides (abstract). J Nucl Med 2006;47Suppl 1:381P.

    Google Scholar 

  16. Harris BE, Bailey DL, Roach PJ, Schembri GP, Ho Shon IA, Chicco P, et al. A clinical comparison between traditional planar V/Q images and planar images generated from SPECT V/Q scintigraphy. Nucl Med Commun 2008;29:323–330.

    Article  PubMed  Google Scholar 

  17. Gottschalk A, Juni JE, Sostman HD, Coleman RE, Thrall J, McKusick KA, et al. Ventilation-perfusion scintigraphy in the PIOPED study. Part I: Data collection and tabulation. J Nucl Med 1993;34:1109–1118.

    PubMed  CAS  Google Scholar 

  18. Gottschalk A, Sostman HD, Coleman RE, Juni JE, Thrall J, McKusick KA, et al. Ventilation-perfusion scintigraphy in the PIOPED study. Part II: Evaluation of the scintigraphic criteria and interpretations. J Nucl Med 1993;34:1119–1126.

    PubMed  CAS  Google Scholar 

  19. Townsend DW, Spinks TJ, Jones T, Geissbühler A, Defrise M, Gilardi M-C, et al. Three dimensional reconstruction of PET data from a multi-ring camera. IEEE Trans Nucl Sci 1989;36:1056–1065.

    Article  CAS  Google Scholar 

  20. Tan P, Bailey DL, Meikle SR, Eberl S, Fulton RR, Hutton BF. A scanning line source for simultaneous emission and transmission measurements in SPECT. J Nucl Med 1993;34:1752–1760.

    PubMed  CAS  Google Scholar 

  21. Fleming JS. A technique for using CT images in attenuation correction and quantification in SPECT. Nucl Med Commun 1989;10:83–97.

    Article  PubMed  CAS  Google Scholar 

  22. Jaszczak RJ, Greer KL, Floyd CE, Harris CG, Coleman RE. Improved SPECT quantitation using compensation for scattered photons. J Nucl Med 1984;25:893–900.

    PubMed  CAS  Google Scholar 

  23. Fleming JS. Technique for the use of standard outlines for attenuation correction and quantification in SPECT. Nucl Med Commun 1990;11:685–696.

    Article  PubMed  CAS  Google Scholar 

  24. Licho R, Glick SJ, Xia W, Pan TS, Penney BC, King MA. Attenuation compensation in 99mTc SPECT brain imaging: a comparison of the use of attenuation maps derived from transmission versus emission data in normal scans. J Nucl Med 1999;40:456–463.

    PubMed  CAS  Google Scholar 

  25. Meikle SR, Hutton BF, Bailey DL. A transmission dependent method for scatter correction in SPECT. J Nucl Med 1994;35:360–367.

    PubMed  CAS  Google Scholar 

  26. Mortelmans L, Nuyts J, Van Pamel G, Van den Maegdenbergh V, De Roo M, Suetens P. A new thresholding method for volume determination by SPECT. Eur J Nucl Med 1986;12:284–290.

    Article  PubMed  CAS  Google Scholar 

  27. Chandler ST. A comparison of liver-spleen ratios and uptakes obtained using planar and tomographic techniques. Nucl Med Commun 1989;10:297–307.

    Article  PubMed  CAS  Google Scholar 

  28. Gustafsson A, Jacobsson L, Johansson A, Moonen M, Tylen U, Bake B. Evaluation of various attenuation corrections in lung SPECT in healthy subjects. Nucl Med Commun 2003;24:1087–1095.

    Article  PubMed  CAS  Google Scholar 

  29. Kalemis A, Binnie D, Bailey DL, Flower MA, Ott RJ. Scaling images using their background ratio: an application in statistical comparisons of images. Phys Med Biol 2003;48:1539–1549.

    Article  PubMed  CAS  Google Scholar 

  30. Michel C, Bol A, De Volder AG, Goffinet AM. Online brain attenuation correction in PET: towards a fully automated data handling in a clinical environment. Eur J Nucl Med 1989;15:712–718.

    Article  PubMed  CAS  Google Scholar 

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Correspondence to Dale L. Bailey.

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Bailey, D.L., Schembri, G.P., Harris, B.E. et al. Generation of planar images from lung ventilation/perfusion SPECT. Ann Nucl Med 22, 437–445 (2008). https://doi.org/10.1007/s12149-007-0120-1

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  • DOI: https://doi.org/10.1007/s12149-007-0120-1

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