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Comparison of FDG-PET findings of brain metastasis from non-small-cell lung cancer and small-cell lung cancer

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Abstract

Objective

We compared the F-18 fluorodeoxyglucose positron emission tomography (FDG-PET) findings of brain metastasis between patients with non-small-cell lung cancer (NSCLC) and small cell lung cancer (SCLC).

Methods

A whole-body FDG and a brain PET were performed in 48 patients (31 men, 17 women; 57 ± 9 years, 42 NSCLC, 6 SCLC), who had brain metastasis on magnetic resonance (MR). All primary lung lesions were detected by FDG-PET and confirmed pathologically. We analyzed the PET findings, lesion sizes, and the pathological result of primary lung cancer.

Results

Of the 48 patients, 31 (64.6%) showed hypermetabolic lesions on FDG-PET of the brain image, and 14 (29.2%) showed hypometabolic lesions. Three patients (6.3%) had both hypermetabolic and hypometabolic lesions. On the lesion-based analysis, 74 lesions (67.3%) showed hypermetabolism on FDG-PET, and 36 lesions (32.7%) showed hypometabolism. All primary lung lesions were hypermetabolic on FDG-PET. When the FDG findings of metastatic brain lesions were analyzed with the pathological types of primary lung cancer, NSCLC was more frequently associated with hypermetabolic metastatic brain lesions than SCLC (80% and 26.7%, respectively, P < 0.01). On comparing the sizes of metastatic lesions between SCLC (1.3 ± 1.2 cm) and NSCLC (1.8 ± 1.2 cm), lesions of <1 cm were more frequent in SCLC than in NSCLC (P = 0.012). But no significant relationship was found between the size and PET finding of metastatic lesion (P = 0.412).

Conclusions

Even when the primary lesion of lung cancer showed hypermetabolism in FDG-PET, FDG accumulation in metastatic brain lesions was variable. One-third of brain metastases from lung cancer showed hypometabolism. NSCLC was more frequently associated with hypermetabolic metastatic brain lesions than SCLC. The PET findings of brain lesions were affected not only by the size of lesion but also by its biological characteristics.

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Authors and Affiliations

  1. Department of Nuclear Medicine, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, 110-744, Seoul, Korea

    Ho-Young Lee, June-Key Chung, Jae Min Jeong, Dong Soo Lee & Myung Chul Lee

  2. Tumor Immunity Medical Research Center, Seoul National University College of Medicine, Seoul, Korea

    June-Key Chung & Jae Min Jeong

  3. Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea

    June-Key Chung & Jae Min Jeong

  4. Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Korea

    Dong Gyu Kim & Hee Won Jung

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  1. Ho-Young Lee
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  2. June-Key Chung
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  3. Jae Min Jeong
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  4. Dong Soo Lee
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Correspondence to June-Key Chung.

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Lee, HY., Chung, JK., Jeong, J.M. et al. Comparison of FDG-PET findings of brain metastasis from non-small-cell lung cancer and small-cell lung cancer. Ann Nucl Med 22, 281–286 (2008). https://doi.org/10.1007/s12149-007-0104-1

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  • DOI: https://doi.org/10.1007/s12149-007-0104-1

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