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Comprehensive network map of interferon gamma signaling

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Journal of Cell Communication and Signaling Aims and scope

Abstract

Interferon gamma (IFN-γ), is a cytokine, which is an important regulator of host defense system by mediating both innate and adaptive immune responses. IFN-γ signaling is primarily associated with inflammation and cell-mediated immune responses. IFN-γ is also represented as antitumor cytokine which facilitates immunosurveillance in tumor cells. In addition, IFN-γ mediated signaling also elicits pro-tumorigenic transformations and promotes tumor progression. Impact of IFN-γ signaling in mammalian cells has been widely studied which indicate that IFN-γ orchestrates distinct cellular functions including immunomodulation, leukocyte trafficking, apoptosis, anti-microbial, and both anti- and pro-tumorigenic role. However, a detailed network of IFN-γ signaling pathway is currently lacking. Therefore, we systematically curated the literature information pertaining to IFN-γ signaling and develop a comprehensive signaling network to facilitate better understanding of IFN-γ mediated signaling. A total of 124 proteins were catalogued that were experimentally proven to be involved in IFN-γ signaling cascade. These 124 proteins were found to participate in 81 protein-protein interactions, 94 post-translational modifications, 20 translocation events, 54 activation/inhibiton reactions. Further, 236 differential expressed genes were also documented in IFN-γ mediated signaling. IFN-γ signaling pathway is made freely available to scientific audience through NetPath at (http://www.netpath.org/pathways?path_id=NetPath_32). We believe that documentation of reactions pertaining to IFN-γ signaling and development of pathway map will facilitate further research in IFN-γ associated human diseases including cancer.

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Abbreviations

IFN-γ /IFNG:

Interferon gamma

IFNGR1:

IFN-γ receptor subunit 1

IFNGR2:

IFN-γ receptor subunit 2

STAT:

Signal transducer and activator of transcription protein

ISGs:

Interferon stimulated genes

PPI:

Protein-protein interaction

SBML:

Systems Biology Markup Language

BioPAX:

Biological Pathway Exchange

PTM:

Post-translational modification

HPRD:

Human Protein Reference Database

PSI-MI:

Proteomics Standards Initiative for Molecular Interaction

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Acknowledgments

We thank the Department of Biotechnology (DBT), Government of India for research support to the Institute of Bioinformatics, Bangalore. MYB is a recipient of Senior Research Fellowship from Department of Biotechnology (DBT), Government of India. JA is recipient of Senior Research Fellowship from Council of Scientific and Industrial Research (CSIR), Government of India. AAK is recipient of Senior Research Fellowship from Indian Council of Medical Research (ICMR), New Delhi.

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Authors and Affiliations

  1. Institute of Bioinformatics, International Technology Park, Bangalore, 560 066, India

    Mohd Younis Bhat, Hitendra S. Solanki, Jayshree Advani, Aafaque Ahmad Khan, T. S. Keshava Prasad, Harsha Gowda & Aditi Chatterjee

  2. School of Biotechnology, Amrita Vishwa Vidyapeetham, Kollam, 690525, India

    Mohd Younis Bhat

  3. School of Biotechnology, Kalinga Institute of Industrial Technology, Bhubaneswar, 751024, India

    Hitendra S. Solanki & Aafaque Ahmad Khan

  4. Manipal Academy of Higher Education, Manipal, 576104, India

    Jayshree Advani

  5. Center for Systems Biology and Molecular Medicine, Yenepoya Research Centre, Yenepoya (Deemed to be University), Mangalore, 575018, India

    T. S. Keshava Prasad

  6. Division of Cancer Biology, Mitra Biotech, Bangalore, 560099, India

    Saravanan Thiyagarajan

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  1. Mohd Younis Bhat
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Correspondence to Aditi Chatterjee.

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Bhat, M.Y., Solanki, H.S., Advani, J. et al. Comprehensive network map of interferon gamma signaling. J. Cell Commun. Signal. 12, 745–751 (2018). https://doi.org/10.1007/s12079-018-0486-y

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