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Endoscopic ultrasonography (EUS) in the localization of insulinoma

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Abstract

Objective

Endoscopic ultrasonography has been accepted as a sensitive modality for preoperative tumor localization in pancreas. We have aimed to determine the performance characteristics of endoscopic ultrasonography in pancreatic insulinoma localization and evaluation of relationship between the tumor size and serum-c peptide level, lowest glucose level and insulin level.

Methods

Patients suspicious to insulinoma according to clinical and laboratory findings were included. Endoscopic ultrasonography was performed and if a tumor was identified, the patient was referred for surgery.

Results

A total of 52 patients (24 male and 28 female) with mean age of 42.4 years underwent EUS and 43 patients underwent surgery. In one patient, a tumor was identified both by transabdominal ultrasonography and abdominal CT scan. The overall sensitivity and accuracy of endoscopic ultrasonography for detection of insulinoma was 89.5% and 83.7% respectively. The sensitivity of endoscopic ultrasonography for detection of lesions in pancreatic head, body and tail was 92.6%, 78.9%, and 40.0%, respectively. There was no relationship between c-peptide, lowest blood glucose, insulin blood levels and tumor size in surgery.

Conclusion

EUS is an accurate method for detection of insulinoma. The accuracy depends on the location of the tumor and is greatest for tumors in the pancreatic head.

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References

  1. F.J. Service, M.M. McMahon, P.C. O’Brien, D.J. Ballard, Mayo Clin. Proc. 66, 711–719 (1991)

    PubMed  CAS  Google Scholar 

  2. G. Tamburrano, A. Paoloni, D. Pietrobono, E. D’Amico, C. Durante, R. Baldelli, Ital. J. Gastroenterol. Hepatol. 31(Suppl 2), S104–7 (1999), S104–S107

    PubMed  Google Scholar 

  3. J.A. van Heerden, A.J. Edis, F.J. Service, Ann. Surg. 189, 677–682 (1979)

    Article  PubMed  Google Scholar 

  4. C.M. King, R.H. Reznek, J.E. Dacie, J.A. Wass, Clin. Radiol. 49, 295–303 (1994)

    Article  PubMed  Google Scholar 

  5. J. Pitre, O. Soubrane, L. Palazzo, Y. Chapuis, Pancreas 13, 55–60 (1996)

    Article  PubMed  CAS  Google Scholar 

  6. T. Rosch, C.J. Lightdale, J.F. Botet, G.A. Boyce, M.V. Sivak Jr., K. Yasuda, N. Heyder, L. Palazzo, H. Dancygier, V. Schusdziarra, N. Engl. J. Med. 326, 1721–1726 (1992)

    Article  PubMed  CAS  Google Scholar 

  7. N.M. Kuzin, A.V. Egorov, S.A. Kondrashin, A.N. Lotov, N.S. Kuznetzov, J.B. Majorova, World J. Surg. 22, 593–597 (1998)

    Article  PubMed  CAS  Google Scholar 

  8. V. Fendrich, D.K. Bartsch, P. Langer, A. Zielke, M. Rothmund, Dtsch. Med. Wochenschr. 129, 941–946 (2004)

    Article  PubMed  CAS  Google Scholar 

  9. L.B. Nesje, J.E. Varhaug, E.S. Husebye, S. Odegaard, Scand. J. Gastroenterol. 37, 732–737 (2002)

    Article  PubMed  CAS  Google Scholar 

  10. A.K. Galiber, C.C. Reading, J.W. Charboneau, P.F. Sheedy, E.M. James, B. Gorman, C.S. Grant, J.A. van Heerden, R.L. Telander, Radiology 166, 405–408 (1988)

    PubMed  CAS  Google Scholar 

  11. S.A. Wank, J.L. Doppman, D.L. Miller, M.J. Collen, P.N. Maton, R. Vinayek, J.I. Slaff, J.A. Norton, J.D. Gardner, R.T. Jensen, Gastroenterology 92, 905–912 (1987)

    PubMed  CAS  Google Scholar 

  12. F. Gibril, J.C. Reynolds, J.L. Doppman, C.C. Chen, D.J. Venzon, B. Termanini, H.C. Weber, C.A. Stewart, R.T. Jensen, Ann. Intern. Med. 125, 26–34 (1996)

    PubMed  CAS  Google Scholar 

  13. L. Van Hoe, S. Gryspeerdt, G. Marchal, A.L. Baert, L. Mertens, AJR Am. J. Roentgenol. 165, 1437–1439 (1995)

    PubMed  Google Scholar 

  14. P. Legmann, O. Vignaux, B. Dousset, A.J. Baraza, L. Palazzo, I. Dumontier, J. Coste, A. Louvel, G. Roseau, D. Couturier, A. Bonnin, AJR Am. J. Roentgenol. 170, 1315–1322 (1998)

    PubMed  CAS  Google Scholar 

  15. B. Schumacher, H.J. Lubke, T. Frieling, G. Strohmeyer, A.A. Starke, Endoscopy 28, 273–276 (1996)

    Article  PubMed  CAS  Google Scholar 

  16. J.C. Ardengh, P. Rosenbaum, A.J. Ganc, A. Goldenberg, E.J. Lobo, C.A. Malheiros, F. Rahal, A.P. Ferrari, Gastrointest. Endosc. 51, 552–555 (2000)

    Article  PubMed  CAS  Google Scholar 

  17. C.J. Lightdale, J.F. Botet, J.M. Woodruff, M.F. Brennan, Cancer 68, 1815–1820 (1991)

    Article  PubMed  CAS  Google Scholar 

Download references

Acknowledgment

We thank Dr. Shahin Merat, Dr. Alireza Sajadi and Dr. Siavosh Nasseri-Moghaddam for their help to edit this article.

Funding: The authors declare that there is no conflict of interest that would prejudice the impartiality of this scientific work.

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Authors and Affiliations

  1. Digestive Disease Research Center, Medical Sciences/University of Tehran, Shariati Hospital, North Kargar Ave, 14117-13135, Tehran, Iran

    Rasoul Sotoudehmanesh, Shadi Shahraeeni, Sanaz Ainechi, Fatemeh Zeinali & Shadi Kolahdoozan

  2. Department of Surgery, Medical Sciences/University of Tehran, Shariati Hospital, North Kargar Ave, 14117-13135, Tehran, Iran

    Anooshirvan Hedayat

  3. Islamic Azad University, Tehran School of Medical Sciences, Tehran, Iran

    Nahid Shirazian

Authors
  1. Rasoul Sotoudehmanesh
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  2. Anooshirvan Hedayat
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  3. Nahid Shirazian
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  4. Shadi Shahraeeni
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  5. Sanaz Ainechi
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  6. Fatemeh Zeinali
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  7. Shadi Kolahdoozan
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Correspondence to Rasoul Sotoudehmanesh.

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Sotoudehmanesh, R., Hedayat, A., Shirazian, N. et al. Endoscopic ultrasonography (EUS) in the localization of insulinoma. Endocr 31, 238–241 (2007). https://doi.org/10.1007/s12020-007-0045-4

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  • DOI: https://doi.org/10.1007/s12020-007-0045-4

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