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Variation of Heart-to-Mediastinal Ratio in 123I-mIBG Cardiac Sympathetic Imaging: Its Affecting Factors and Potential Corrections

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Abstract

Studies have repeatedly shown the utility of 123I-mIBG cardiac sympathetic imaging for identifying symptomatic heart failure patients most likely to experience adverse cardiac events. Delayed heart-to-mediastinal ratio (H/M) and washout rate derived from meta-iodobenzylguanidine (mIBG) scintigraphy have been used to monitor response to medical treatment. However, there is great variation of H/M ratio among publications from various institutions. The current article systemically reviews factors that can potentially affect H/M ratio, particularly the acquisition parameters, and proposes new approaches and/or procedures to standardize the imaging procedure and minimize the variation of H/M among institutions.

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Disclosure / Conflicts of interest

W. Chen: none; Q. Cao: none; V. Dilsizian: receives grant support and serves on the Advisory Board of GE Healthcare.

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Authors and Affiliations

  1. Diagnostic Radiology and Nuclear Medicine, University of Maryland Medical Center, 22 South Greene Street, Room N2W78, Baltimore, MD, 21201, USA

    Wengen Chen, Qi Cao & Vasken Dilsizian

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  1. Wengen Chen
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  2. Qi Cao
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  3. Vasken Dilsizian
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Correspondence to Wengen Chen.

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Chen, W., Cao, Q. & Dilsizian, V. Variation of Heart-to-Mediastinal Ratio in 123I-mIBG Cardiac Sympathetic Imaging: Its Affecting Factors and Potential Corrections. Curr Cardiol Rep 13, 132–137 (2011). https://doi.org/10.1007/s11886-010-0157-y

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  • DOI: https://doi.org/10.1007/s11886-010-0157-y

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