Skip to main content

Advertisement

SpringerLink
Log in

Intensity-modulated radiation therapy for orbital lymphoma

  • Original Article
  • Published:
Radiation Medicine Aims and scope Submit manuscript

Abstract

Purpose

Orbital manifestations of non-Hodgkin’s lymphoma (NHL) are rare and accounts for only 1% of all cases of NHL. There have been no reports of treating orbital lymphoma using intensity-modulated radiotherapy (IMRT).

Materials and methods

Four patients were treated at our institution for orbital lymphoma using IMRT. Radiotherapy (RT) plans using wedged pair fields were developed for comparison. Clinical results using IMRT are presented and a dosimetric analysis between IMRT and RT was performed.

Results

All patients had a complete response based on their physical examinations and post-IMRT imaging. Symptoms that had been present at initial presentation resolved in all patients during the course of the treatment. All four patients experienced only grade 1 dry eye syndrome and keratitis. The average dose to the contralateral orbit, lacrimal gland, and lens were all significantly reduced (P < 0.01) in IMRT patients as compared to the RT patients. IMRT reduced the V5 and V10 for the contralateral lens, orbit, and lacrimal gland and the optic chiasm (P < 0.05).

Conclusion

IMRT is feasible when treating orbital lymphoma and reduces dose to critical structures while providing excellent dose coverage of target volumes. IMRT offers patients with orbital lymphoma excellent clinical outcomes, similar to conventional RT, with no increased toxicity.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Fitzpatrick PJ, Macko S. Lymphoreticular tumors of the orbit. Int J Radiat Oncol Biol Phys 1984;10:333–340.

    PubMed  CAS  Google Scholar 

  2. Bolek TW, Moyses HM, Marcus RB Jr, Gorden L 3rd, Maiese RL, Almasri NM, et al. Radiotherapy in the management of orbital lymphoma. Int J Radiat Oncol Biol Phys 1999;44:31–36.

    Article  PubMed  CAS  Google Scholar 

  3. Chao CK, Lin HS, Devineni VR, Smith M. Radiation therapy for primary orbital lymphoma. Int J Radiat Oncol Biol Phys 1995;31:929–934.

    PubMed  CAS  Google Scholar 

  4. Esik O, Ikeda H, Mukai K, Kaneko A. A retrospective analysis of different modalities for treatment of primary orbital non-Hodgkin’s lymphomas. Radiother Oncol 1996;38:13–18.

    Article  PubMed  CAS  Google Scholar 

  5. Pelloski CE, Wilder RB, Ha CS, Hess MA, Cabanillas FF, Cox JD. Clinical stage IEA-IIEA orbital lymphomas: outcomes in the era of modern staging and treatment. Radiother Oncol 2001;59:145–151.

    Article  PubMed  CAS  Google Scholar 

  6. Bessell EM, Henk JM, Wright JE, Whitelocke RA. Orbital and conjunctival lymphoma treatment and prognosis. Radiother Oncol 1988;13:237–244.

    Article  PubMed  CAS  Google Scholar 

  7. Minehan KJ, Martenson JA Jr, Garrity JA, Kurtin PJ, Banks PM, Chen MG, et al. Local control and complications after radiation therapy for primary orbital lymphoma: a case for low-dose treatment. Int J Radiat Oncol Biol Phys 1991;20:791–796.

    PubMed  CAS  Google Scholar 

  8. Bhatia S, Paulino AC, Buatti JM, Mayr NA, Wen BC. Curative radiotherapy for primary orbital lymphoma. Int J Radiat Oncol Biol Phys 2002;54:818–823.

    PubMed  Google Scholar 

  9. Zhou P, Ng AK, Silver B, Li S, Hua L, Mauch PM. Radiation therapy for orbital lymphoma. Int J Radiat Oncol Biol Phys 2005;63:866–871.

    PubMed  Google Scholar 

  10. Hsiung CY, Ting HM, Huang HY, Lee CH, Huang EY, Hsu HC. Parotid-sparing intensity-modulated radiotherapy (IMRT) for nasopharyngeal carcinoma: preserved parotid function after IMRT on quantitative salivary scintigraphy, and comparison with historical data after conventional radiotherapy. Int J Radiat Oncol Biol Phys 2006;66:454–461.

    PubMed  Google Scholar 

  11. Klem ML, Mechalakos JG, Wolden SL, Zelefsky MJ, Singh B, Kraus D, et al. Intensity-modulated radiotherapy for head and neck cancer of unknown primary: toxicity and preliminary efficacy. Int J Radiat Oncol Biol Phys 2008;70:1100–1107.

    PubMed  Google Scholar 

  12. Hein PA, Gladstone DJ, Bellerive MR, Hug EB. Importance of protocol target definition on the ability to spare normal tissue: an IMRT and 3D-CRT planning comparison for intraorbital tumors. Int J Radiat Oncol Biol Phys 2005;62:1540–1548.

    PubMed  Google Scholar 

  13. Reisner ML, Viegas CM, Grazziotin RZ, Santos Batista DV, Carneiro TM, Mendonca de Araujo CM, et al. Retinoblastoma-comparative analysis of external radiotherapy techniques, including an IMRT technique. Int J Radiat Oncol Biol Phys 2007;67:933–941.

    PubMed  Google Scholar 

  14. Martinet S, Ozsahin M, Belkacemi Y, Landmann C, Poortmans P, Oehlere C, et al. Outcome and prognostic factors in orbital lymphoma: a Rare Cancer Network study on 90 consecutive patients treated with radiotherapy. Int J Radiat Oncol Biol Phys 2003;55:892–898

    PubMed  Google Scholar 

  15. Isobe K, Kagami Y, Higuchi K, Kodaira T, Hasegawa M, Shikama N, et al. A multicenter phase II study of local radiation therapy for stage IEA mucosa-associated lymphoid tissue lymphomas: a preliminary report from the Japan Radiation Oncology Group (JAROG). Int J Radiat Oncol Biol Phys 2007;69:1181–1186.

    PubMed  Google Scholar 

  16. Wolden SL, Wexler LH, Kraus DH, Laquaglia MP, Lis E, Meyers PA. Intensity-modulated radiotherapy for head-andneck rhabdomyosarcoma. Int J Radiat Oncol Biol Phys 2005;61:1432–438.

    PubMed  Google Scholar 

  17. Pfeffer MR, Rabin T, Tsvang L, Goffman J, Rosen N, Symon Z. Orbital lymphoma: is it necessary to treat the entire orbit? Int J Radiat Oncol Biol Phys 2004;60:527–530.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Radiation Oncology, The Cancer Institute of New Jersey UMDNJ/Robert Wood Johnson Medical School, 195 Little Albany Street, New Brunswick, NJ, 08903, USA

    Sharad Goyal, Alan Cohler, Jayne Camporeale, Venkat Narra & Ning J. Yue

Authors
  1. Sharad Goyal
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Alan Cohler
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Jayne Camporeale
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Venkat Narra
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Ning J. Yue
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Sharad Goyal.

About this article

Cite this article

Goyal, S., Cohler, A., Camporeale, J. et al. Intensity-modulated radiation therapy for orbital lymphoma. Radiat Med 26, 573–581 (2008). https://doi.org/10.1007/s11604-008-0276-1

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11604-008-0276-1

Key words

Search

Navigation