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Automatic volumetric measurement of segmented brain structures on magnetic resonance imaging

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Abstract

Purpose

The purpose of this study was to produce a fully automatic volumetric segmented brain image system (AVSIS) and to evaluate its utility for measuring hippocampal volumes and total intracranial volume (TIV).

Materials and methods

We developed a combination technique comprising an anatomical standardization technique to measure TIV, whole brain volume (WBV), and hippocampal volume obtained by magnetic resonance (MR) imaging. Altogether, 15 healthy volunteers and 15 patients with Alzheimer's disease (AD) underwent three-dimensional spoiled gradient echo (3D-SPGR) imaging. Three measurements were performed by manual volumetry as the gold standard, a previous semiautomatic method, and our new method, AVSIS.

Results

WBV and hippocampal volume in the AD group were significantly smaller than those in the healthy volunteer group measured by the semiautomatic method, manual method, and AVSIS. Each volume measured by AVSIS or semiautomatic method correlated with that measured by the manual method. The correlation coefficients between TIVs, WBVs, or hippocampal volumes measured by AVSIS and the manual method were 0.910, 0.902, and 0.918, respectively; the correlation coefficients between TIVs, or WBVs, measured by the previous semiautomatic method and the manual method were 0.875, and 0.886, respectively.

Conclusion

We developed a system for a fully automatic measurement of segmented brain structures and obtained good results.

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Author information

Authors and Affiliations

  1. Department of Radiology and Nuclear Medicine, Hyogo Brain and Heart Center, 520 Saisho-Ko, Himeji, Hyogo, 670-0981, Japan

    Kazunari Ishii, Atsushi K. Kono, Hiroki Sasaki, Naokazu Miyamoto & Tetsuya Fukuda

  2. Clinical Application Technology (CAT) Group, Daiichi Radioisotope Laboratories, Tokyo, Japan

    Tsutomu Soma

  3. Department of Medical Engineering, School of Allied Health Sciences, Faculty of Medicine, Osaka University, Suita, Osaka, Japan

    Tsutomu Soma

  4. Department of Medical Physics and Engineering, Division of Medical Technology and Science, Course of Health Science, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan

    Kenya Murase

Authors
  1. Kazunari Ishii
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  2. Tsutomu Soma
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  3. Atsushi K. Kono
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  4. Hiroki Sasaki
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  5. Naokazu Miyamoto
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  6. Tetsuya Fukuda
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  7. Kenya Murase
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Corresponding author

Correspondence to Kazunari Ishii.

Additional information

This article was presented at the 33rd annual meeting of the Japanese Society for Magnetic Resonance in Medicine, Tokyo, Japan in 2005.

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Ishii, K., Soma, T., Kono, A. et al. Automatic volumetric measurement of segmented brain structures on magnetic resonance imaging. Radiat Med 24, 422–430 (2006). https://doi.org/10.1007/s11604-006-0048-8

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  • DOI: https://doi.org/10.1007/s11604-006-0048-8

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