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[68Ga]-Albumin-PET in the Monitoring of Left Ventricular Function in Murine Models of Ischemic and Dilated Cardiomyopathy: Comparison with Cardiac MRI

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Abstract

Purpose

The purpose of this study is to evaluate left ventricular functional parameters in healthy mice and in different murine models of cardiomyopathy with the novel blood pool (BP) positron emission tomography (PET) tracer [68Ga]-albumin.

Procedures

ECG-gated microPET examinations were obtained in healthy mice, and mice with dilative (DCM) and ischemic cardiomyopathy (ICM) using the novel BP tracer [68Ga]-albumin (AlbBP), as well as [18F]-FDG microPET. Cine-magnetic resonance imaging (MRI) examination performed on a clinical 1.5-T MRI provided the reference standard measurements.

Results

When considering the combined group of healthy controls, DCM and ICM AlbBP-PET significantly overestimated the magnitudes of EDV (AlbBP, 181 ± 86 μl; cine-MRI, 125 ± 80 μl; P < 0.001) and ESV (AlbBP, 136 ± 92 μl; cine-MRI, 96 ± 77 μl; P < 0.001), whereas the EF (AlbBP, 31 ± 16 %; cine-MRI, 33 ± 21 %; P = 0.910) matched closely to cine-MRI results, as did findings with [18F]-FDG. High correlations were found between the measured cardiac parameters (EDV: R = 0.978, ESV: R = 0.989, and LVEF: R = 0.992).

Conclusions

Measuring left ventricular function in mice with [68Ga]-albumin BP PET is feasible and showed a high correlation compared to cine-MRI, which was used as a reference standard.

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Acknowledgements

Financial support was provided by the Fritz-Bender-Stiftung and the Else Kröner-Fresenius-Stiftung.

Disclosures

None.

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Authors and Affiliations

  1. Department of Nuclear Medicine, Ludwig-Maximilians-University, Klinikum Grosshadern, Munich, Germany

    Andrei Todica, Guido Böning, Sebastian Lehner, Christopher Übleis, Carmen Wängler, Paul Cumming, Peter Bartenstein & Marcus Hacker

  2. Medical Department I, Ludwig-Maximilians-University, Klinikum Grosshadern, Munich, Germany

    Stefan Brunner & Wolfgang Michael Franz

  3. Department of Nuclear Medicine, Technical University Munich, Klinikum Rechts der Isar, Munich, Germany

    Stephan G. Nekolla & Moritz Wildgruber

  4. Department of Molecular Pathology, University of Tübingen, Tübingen, Germany

    Martina Sauter & Karin Klingel

  5. McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, QC, Canada

    Carmen Wängler & Ralf Schirrmacher

Authors
  1. Andrei Todica
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  2. Stefan Brunner
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  3. Guido Böning
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  4. Sebastian Lehner
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  11. Paul Cumming
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  14. Wolfgang Michael Franz
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  15. Marcus Hacker
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Corresponding author

Correspondence to Marcus Hacker.

Additional information

Andrei Todica and Stefan Brunner contributed equally to this work.

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Todica, A., Brunner, S., Böning, G. et al. [68Ga]-Albumin-PET in the Monitoring of Left Ventricular Function in Murine Models of Ischemic and Dilated Cardiomyopathy: Comparison with Cardiac MRI. Mol Imaging Biol 15, 441–449 (2013). https://doi.org/10.1007/s11307-013-0618-y

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  • DOI: https://doi.org/10.1007/s11307-013-0618-y

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