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Initial Results with 11C-Acetate Positron Emission Tomography/Computed Tomography (PET/CT) in the Staging of Urinary Bladder Cancer

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Abstract

Purpose

To investigate the utility of 11C-acetate positron emission tomography/computed tomography (PET/CT) for staging of bladder cancer and response assessment after neoadjuvant chemotherapy.

Procedures

Seventeen patients underwent 11C-acetate PET/CT ≤1 month before radical cystectomy (RC) and pelvic lymph node dissection (PLND). Ten patients had undergone neoadjuvant chemotherapy prior to PET. Histopathology from RC and PLND (n = 16) or nodal biopsy (n = 1) served as gold standard.

Results

Eight of 10 residual tumors showed abnormal 11C-acetate uptake; two cases of residual TiS were false negative, three cases were false positive, and three true negative. Three patients showed true positive uptake in LN. False positive uptake occurred in 14 LN regions secondary to granulomatous disease after prior intravesical Bacillus Calmette–Guerin (BCG) therapy.

Conclusions

11C-acetate has good sensitivity for bladder cancer and LN metastases. However, false positive uptake due to inflammation or granulomatous infection can occur, limiting the staging utility of 11C-acetate after prior intravesical BCG therapy.

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Conflicts of Interest

The authors declare that they have no conflicts of interest

Author information

Author notes

  1. Seng C. Ong

    Present address: Nuclear Medicine and PET Centre, Department of Diagnostic Radiology, Mount Elizabeth Hospital, 3 Mount Elizabeth, Singapore, 228510, Singapore

Authors and Affiliations

  1. Department of Radiology, Nuclear Medicine, Memorial Sloan-Kettering Cancer Center, 1275 York Ave., Box 77, New York, NY, 10065, USA

    Heiko Schöder, Seng C. Ong & Steven M. Larson

  2. Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA

    Victor E. Reuter

  3. Department of Radiology, Radiochemistry Service, Memorial Sloan-Kettering Cancer Center, New York, NY, USA

    Shangde Cai & Eva Burnazi

  4. Department of Surgery, Urology Service, Memorial Sloan-Kettering Cancer Center, New York, NY, USA

    Guido Dalbagni & Bernard H. Bochner

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  1. Heiko Schöder
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  2. Seng C. Ong
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  4. Shangde Cai
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  6. Guido Dalbagni
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  8. Bernard H. Bochner
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Correspondence to Heiko Schöder.

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Schöder, H., Ong, S.C., Reuter, V.E. et al. Initial Results with 11C-Acetate Positron Emission Tomography/Computed Tomography (PET/CT) in the Staging of Urinary Bladder Cancer. Mol Imaging Biol 14, 245–251 (2012). https://doi.org/10.1007/s11307-011-0488-0

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  • DOI: https://doi.org/10.1007/s11307-011-0488-0

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