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Dual-Time-Point FDG-PET/CT for the Detection of Hepatic Metastases

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Abstract

Purpose

To prove the sensitivity of dual-time-point imaging with 18F-flourodeoxyglucose-positron emission tomography (18F-FDG-PET) of the liver to evaluate possible changes in the tumor-to-background ratio considering an improved detection rate of liver lesions.

Procedures

Image acquisition for the first whole-body scan started at a mean time point of 69 min (55–110 min). The mean time interval between the injection of 18F-FDG and the second delayed scan was 100 min (85–166 min).

Results

Of 90 proven liver metastases in 34 patients, the first scan detected 53 (59%) liver lesions correctly, whereas in the second, delayed scan 81 (90%) lesions were diagnosed correctly (p<0.001). The mean Standardized uptake values in the first and second delayed scan were 6.59 g/ml versus 8.09 g/ml, respectively (p<0.001). Tumor-to-background ratio of the first and second delayed scan were 2.0 and 2.7, respectively (p = 0.04).

Conclusions

Dual-time-point-imaging of the liver showed a significant increase of tumor-to-background ratio and hypermetabolic lesion diameter. Although, 30% of all verified liver lesions could only be detected in the second delayed scan 10% of all malignant liver lesions were missed with FDG-PET.

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Authors and Affiliations

  1. Radiology, University Hospital Vienna, Vienna, Austria

    Albert Dirisamer, Benjamin S. Halpern, Wolfgang Schima, Florian Wolf & Michael Weber

  2. Radiology, Hospital of Wels, Wels, Austria

    Martin Heinisch

  3. Department of Nuclear Medicine, PET/CT Center, St. Vincent’s Hospital, Linz, Austria

    Albert Dirisamer, Martin Heinisch, Mohsen Beheshti & Werner Langsteger

  4. General Hospital Linz, Linz, Austria

    Franz Dirisamer

Authors
  1. Albert Dirisamer
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  2. Benjamin S. Halpern
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  3. Wolfgang Schima
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  4. Martin Heinisch
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  5. Florian Wolf
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  6. Mohsen Beheshti
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  7. Franz Dirisamer
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  8. Michael Weber
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  9. Werner Langsteger
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Correspondence to Albert Dirisamer.

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Dirisamer, A., Halpern, B.S., Schima, W. et al. Dual-Time-Point FDG-PET/CT for the Detection of Hepatic Metastases. Mol Imaging Biol 10, 335–340 (2008). https://doi.org/10.1007/s11307-008-0159-y

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  • DOI: https://doi.org/10.1007/s11307-008-0159-y

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