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11C-l-Methionine Positron Emission Tomography in the Clinical Management of Cerebral Gliomas

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Abstract

Positron emission tomography (PET) using l-[methyl-11C]-methionine (MET) is the most popular amino acid imaging modality in oncology, although its use is restricted to PET centers with an in-house cyclotron facility. This review focuses on the role of MET–PET in imaging of cerebral gliomas. The biological background of tumor imaging with methionine is discussed with particular emphasis on cellular amino acid transport, amino acid utilization in brain, normal metabolism of methionine, and its alterations in cancer. The role of MET–PET in clinical management of cerebral gliomas in initial diagnosis, differentiation of tumor recurrence from radiation injury, grading, prognostication, tumor-extent delineation, biopsy planning, surgical resection and radiotherapy planning, and assessment of response to therapy is also reviewed in detail.

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Authors and Affiliations

  1. Department of Nuclear Medicine/PET, Kettering Medical Center, Dayton, OH, 45429, USA

    Tarun Singhal, Tanjore K. Narayanan, Viney Jain & Joseph Mantil

  2. Department of Psychiatry and Human Behavior and Radiological Sciences, University of California–Irvine, Irvine, CA, 92697, USA

    Jogeshwar Mukherjee

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  1. Tarun Singhal
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  2. Tanjore K. Narayanan
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  4. Jogeshwar Mukherjee
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Correspondence to Joseph Mantil.

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Singhal, T., Narayanan, T.K., Jain, V. et al. 11C-l-Methionine Positron Emission Tomography in the Clinical Management of Cerebral Gliomas. Mol Imaging Biol 10, 1–18 (2008). https://doi.org/10.1007/s11307-007-0115-2

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