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Correlation of GLUT-1 Overexpression, Tumor Size, and Depth of Invasion with 18F-2-fluoro-2-deoxy-d-glucose Uptake by Positron Emission Tomography in Colorectal Cancer

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Abstract

We investigated the wide variability of 18F-2-fluoro-2-deoxy-d-glucose (FDG) uptake, semiquantified as standardized uptake value (SUV), in positron emission tomography (PET) scanning, in 20 patients with colorectal cancer (CRC), including 1 with synchronous hepatic metastasis. The sensitivity of PET in CRC diagnosis was 100%, with a mean SUV of 8.0 (3.1–11.9). Tumor size and depth of invasion were associated with higher SUVs (P=.0004, .042, respectively). Strong glucose transporter-1 (GLUT-1) expression had significantly positive correlation with the SUV (r=.619, P=.003). GLUT-1 expression revealed positive staining in 17 (85%) of the 20 primary lesions. The central part of the tumor, thought to be relatively hypoxic, had stronger GLUT-1 expression and a higher SUV than the periphery, in both the primary tumor and hepatic metastatic foci. Our data suggest that the SUVs of FDG uptake in PET may be a noninvasive biomarker for advanced CRC, indicative of a large hypoxic tumor with deep invasion.

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Acknowledgments

We thank Dr. Ichiro Higuchi of the Department of Nuclear Medicine and Tracer Kinetics, Osaka University, for technical assistance with PET imaging, and Dr. Chew Yee Ngan, Dr. Hideyuki Hemmi, Dr. Kyo Naganori, for his help in preparing this manuscript. This work was supported by a Grant-in Aid for Cancer Research from the Ministry of Education, Science, Sports, and Culture Technology, Japan (to H.Y.). This study was supported in part by the Japan-China Sasakawa Medical Fellowship.

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Authors and Affiliations

  1. Department of Surgery and Clinical Oncology, Graduate School of Medicine, Osaka University, 2-2 Yamada-oka, Suita-City, Osaka, 565-0871, Japan

    Jinyu Gu, Hirofumi Yamamoto, Hiroki Fukunaga, Katsuki Danno, Ichiro Takemasa, Masataka Ikeda, Mitsugu Sekimoto & Morito Monden

  2. Department of General Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, China

    Jinyu Gu

  3. Department of Nuclear Medicine and Tracer Kinetics, Graduate School of Medicine, Osaka University, Osaka, 565-0871, Japan

    Mitsuaki Tatsumi & Jun Hatazawa

  4. Department of Radiology, Graduate School of Medicine, Kyoto Prefectural University of Medicine, Kyoto, 602-8566, Japan

    Tsunehiko Nishimura

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  1. Jinyu Gu
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Correspondence to Hirofumi Yamamoto.

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Gu, J., Yamamoto, H., Fukunaga, H. et al. Correlation of GLUT-1 Overexpression, Tumor Size, and Depth of Invasion with 18F-2-fluoro-2-deoxy-d-glucose Uptake by Positron Emission Tomography in Colorectal Cancer. Dig Dis Sci 51, 2198–2205 (2006). https://doi.org/10.1007/s10620-006-9428-2

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