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Prognostic significance of 18F-FDG uptake in primary osteosarcoma after but not before chemotherapy: a possible association with autocrine motility factor/phosphoglucose isomerase expression

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Abstract

Response to neoadjuvant chemotherapy is a significant prognostic factor for osteosarcoma (OS). 18-F-fluorodeoxy-d-glucose (FDG) positron emission tomography (PET) is a noninvasive imaging modality that correlates with histological grading in musculoskeletal sarcomas. To determine the prognostic value of FDG PET in patients receiving chemotherapy, 13 patients were evaluated by FDG-PET, and followed for more than 4 years. FDG PET standardized uptake values before (SUV1) and after (SUV2) chemotherapy were analyzed and correlated with the expression of metastasis-related glycolytic enzyme, autocrine motility factor (AMF)/phosphoglucose isomerase (PGI) by immunohistochemical examination in surgically excised tumors. Although mean SUV1 for OS patients with metastatic lesions were similar to those in the completely disease-free (CDF) group (6.5 vs. 6.6, respectively, P = 0.975), mean SUV2 for OS with metastatic lesions were significantly higher than those in the CDF group (5.1 vs. 2.5, respectively, P = 0.0445). Interestingly, immunohistochemical analysis using anti-AMF/PGI antibody revealed that SUV2 correlated significantly with the AMF/PGI staining titers (P = 0.0303), while no correlation between SUV1 and the AMF/PGI staining titers existed (P = 0.964). The present study suggests that FDG PET after chemotherapy may provide information for AMF/PGI-related metastatic potentiality of residual tumors located out side of the area surgically resected afterward, and then lead to a useful prediction of the patients’ prognosis.

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Abbreviations

AMF:

Autocrine motility factor

DOD:

Death of disease

FDG:

18-F-Fluorodeoxy-d-glucose

IHC:

Immunohistochemistry

NED:

No evidence of disease

OS:

Osteosarcoma

PET:

Positron emission tomography

PGI:

Phosphoglucose isomerase

PHI:

Phosphohexose isomerase

ROI:

Region of interest

SUV:

Standardized uptake value

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Acknowledgement

This work was supported in part by a Grant-in-Aid for scientific research (C) 16591472 (H.W.) from the Japan Society for the Promotion of Science.

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Authors and Affiliations

  1. Department of Orthopaedic Surgery, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan

    Junko Sato, Takashi Yanagawa & Kenji Takagishi

  2. Department of Pathology, Omiya Medical Center, Jichi University, Omiya, Saitama, Japan

    Yoh Dobashi

  3. Department of Physical Therapy, Gunma University School of Health Science, 3-39-22, Showa, Maebashi, Gunma, 371-8511, Japan

    Takehiko Yamaji & Hideomi Watanabe

Authors
  1. Junko Sato
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  2. Takashi Yanagawa
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  3. Yoh Dobashi
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  4. Takehiko Yamaji
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  6. Hideomi Watanabe
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Correspondence to Hideomi Watanabe.

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Sato, J., Yanagawa, T., Dobashi, Y. et al. Prognostic significance of 18F-FDG uptake in primary osteosarcoma after but not before chemotherapy: a possible association with autocrine motility factor/phosphoglucose isomerase expression. Clin Exp Metastasis 25, 427–435 (2008). https://doi.org/10.1007/s10585-008-9147-5

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