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Normal limits of gated blood pool SPECT count-based regional cardiac function parameters

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The International Journal of Cardiovascular Imaging Aims and scope Submit manuscript

Abstract

Purpose Computations of left and right ventricular (LV and RV) gated blood pool SPECT (GBPS) ejection fraction (EF) have been well validated against other imaging modalities. As GBPS images depict the entire extent of both blood pools, it is possible to compute not only global but also regional biventricular function parameters, which have the prospect of being clinically useful for planning cardiac resynchronization therapy. This investigation sought to establish LV and RV count-based GBPS regional functional normal limits and to quantify their reproducibility. Methods and materials Count-versus-time curves were fit to third-order Fourier series for each of 17 LV and RV sub-volumes to compute global and regional EF, timing, phase and dyssynchrony parameters. Algorithms were applied to data for 40 normal controls (NLs) and 15 patients with CHF. To assess reproducibility, data were reprocessed a second time, blinded to initial calculations. Results There were no statistically significant differences between any initial and reprocessed LV or RV parameters for NLs or patients with CHF. Percent of subjects categorized as abnormal were the same for initial and reprocessed parameters (McNemar’s differences = 0–7%, P > 0.05 for each parameter). Most parameters were significantly different for patients with CHF versus NLs. Normal limits for the new technique agreed well with the literature for other imaging methods, and RV normal limits closely paralleled LV limits. Conclusion GBPS global and regional LV and RV normal limits are reproducible, and application of these normal limits to patients with CHF results in reproducible detection of functional abnormalities.

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Acknowledgments

We would like to thank Jing Han for her expert assistance with the statistical analysis reported for this report. This work received material support of the Saint Francis Cardiac Research Foundation. Kenneth Nichols shares in royalties for BP-SPECT algorithms.

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Authors and Affiliations

  1. Division of Nuclear Medicine, North Shore Long Island Jewish Health System, 270-05 76th Avenue, New Hyde Park, NY, 11040, USA

    Kenneth J. Nichols & Christopher J. Palestro

  2. Division of Molecular Imaging, North Shore Long Island Jewish Health System, New Hyde Park, NY, USA

    Kenneth J. Nichols & Christopher J. Palestro

  3. Cardiac Imaging Research Program, St. Francis Hospital, Roslyn, NY, USA

    Kenneth J. Nichols, Andrew Van Tosh & Nathaniel Reichek

  4. The Division of Nuclear Medicine, OLV Hospital, Aalst, Belgium

    Pieter De Bondt

  5. The Division of Cardiology, Beth-Israel Hospital, New York, NY, USA

    Steven R. Bergmann

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  1. Kenneth J. Nichols
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  2. Andrew Van Tosh
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  3. Pieter De Bondt
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  4. Steven R. Bergmann
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  5. Christopher J. Palestro
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  6. Nathaniel Reichek
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Correspondence to Kenneth J. Nichols.

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Nichols, K.J., Van Tosh, A., De Bondt, P. et al. Normal limits of gated blood pool SPECT count-based regional cardiac function parameters. Int J Cardiovasc Imaging 24, 717–725 (2008). https://doi.org/10.1007/s10554-008-9304-6

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  • DOI: https://doi.org/10.1007/s10554-008-9304-6

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