Abstract
Purpose
To assess cardiac motion-induced signal loss in diffusion-weighted magnetic resonance imaging (DWI) of the liver using dynamic DWI.
Materials and methods
Three volunteers underwent dynamic coronal DWI of the liver under breathholding, in the diastolic (DWIdiast) or systolic (DWIsyst) cardiac phase, and with motion probing gradients (MPGs) in phase encoding (P, left–right), frequency encoding (M, superior–inferior), or slice select (S, anterior–posterior) direction. Liver-to-background contrasts (LBCs) of DWIsyst were compared to those of DWIdiast, for both the left and right liver lobes, using nonparametric tests. Signal decrease ratios (SDRs) were calculated as (1−(LBCDWIsyst/LBCDWIdiast)) × 100%. DWIsyst was further analyzed to determine which direction of MPGs was most affected by cardiac motion.
Results
In the left liver lobe, LBCs of DWIsyst (median 3.35) were significantly lower (P < 0.0001) than those of DWIdiast (median 4.84). In the right liver lobe, LBCs of DWIsyst (median 4.17) were also significantly lower (P < 0.0001) than those of DWIdiast (median 5.35 ). SDRs of the left and right liver lobes were 25.5% and 17.3%, respectively. In DWIsyst, the significantly lowest (P < 0.05) LBCs were observed in the M direction (left liver lobe) and P direction (right liver lobe) of MPGs.
Conclusion
Signal intensity of both liver lobes are affected by cardiac motion in DWI. In the left liver lobe, signal loss especially occurs in the superior–inferior direction of MPGs, whereas in the right lobe, signal loss especially occurs in the left-right direction of MPGs.
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References
Naganawa S, Kawai H, Fukatsu H, Sakurai Y, Aoki I, Miura S, Mimura T, Kanazawa H, Ishigaki T (2005) Diffusion-weighted imaging of the liver: technical challenges and prospects for the future. Magn Reson Med Sci 4: 175–186
Low RN (2007) Abdominal MRI advances in the detection of liver tumours and characterization. Lancet Oncol 8: 525–535
Taouli B, Tolia AJ, Losada M, Babb JS, Chan ES, Bannan MA, Tobias H (2007) Diffusion-weighted MRI for quantification of liver fibrosis: preliminary experience. AJR Am J Roentgenol 189: 799–806
Koinuma M, Ohashi I, Hanafusa K, Shibuya H (2005) Apparent diffusion coefficient measurements with diffusion-weighted magnetic resonance imaging for evaluation of hepatic fibrosis. J Magn Reson Imaging 22: 80–85
Mürtz P, Flacke S, Träber F, van den Brink JS, Gieseke J, Schild HH (2002) Abdomen: diffusion-weighted MR imaging with pulse-triggered single-shot sequences. Radiology 224: 258–264
Nasu K, Kuroki Y, Sekiguchi R, Kazama T, Nakajima H (2006) Measurement of the apparent diffusion coefficient in the liver: is it a reliable index for hepatic disease diagnosis?. Radiat Med 24: 438–444
Kandpal H, Sharma R, Madhusudhan KS, Kapoor KS (2009) Respiratory-triggered versus breath-hold diffusion-weighted MRI of liver lesions: comparison of image quality and apparent diffusion coefficient values. AJR Am J Roentgenol 192: 915–922
Nasu K, Kuroki Y, Fujii H, Minami M (2007) Hepatic pseudo-anisotropy: a specific artifact in hepatic diffusion-weighted images obtained with respiratory triggering. MAGMA 20: 205–211
Conover WJ (1999) Practical nonparametric statistics. Wiley, New York
Nasu K, Kuroki Y, Minami M (2009) Feasibility of diffusion-weighted imaging under split breath-hold acquisition and postprocessing (DWI-SBAP): an attempt to suppress hepatic pseudo-anisotropy. Jpn J Radiol 27: 78–85
Greitz D, Wirestam R, Franck A, Nordell B, Thomsen C, Ståhlberg F (1992) Pulsatile brain movement and associated hydrodynamics studied by magnetic resonance phase imaging. The Monro-Kellie doctrine revisited. Neuroradiology 34: 370–380
Norris DG (2001) Implications of bulk motion for diffusion-weighted imaging experiments: effects, mechanisms, and solutions. J Magn Reson Imaging 13: 486–495
Robson MD, Porter DA (2005) Reconstruction as a source of artifact in non-gated single-shot diffusion-weighted EPI. Magn Reson Imaging 23: 899–905
Taouli B, Vilgrain V, Dumont E, Daire JL, Fan B, Menu Y (2003) Evaluation of liver diffusion isotropy and characterization of focal hepatic lesions with two single-shot echo-planar MR imaging sequences: prospective study in 66 patients. Radiology 226: 71–78
Kwee TC, Takahara T, Koh DM, Nievelstein RA, Luijten PR (2008) Comparison and reproducibility of ADC measurements in breathhold, respiratory triggered, and free-breathing diffusion-weighted MR imaging of the liver. J Magn Reson Imaging 28: 1141–1148
Acknowledgments
This work was partly funded by a grant of the Dutch scientific foundation (NWO) for T.T.
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Open Access This is an open access article distributed under the terms of the Creative Commons Attribution Noncommercial License (https://creativecommons.org/licenses/by-nc/2.0), which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
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Kwee, T.C., Takahara, T., Niwa, T. et al. Influence of cardiac motion on diffusion-weighted magnetic resonance imaging of the liver. Magn Reson Mater Phy 22, 319–325 (2009). https://doi.org/10.1007/s10334-009-0183-1
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DOI: https://doi.org/10.1007/s10334-009-0183-1