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Advances in research on animal models of rheumatoid arthritis

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Abstract

At present, rheumatoid arthritis (RA) is considered a type of autoimmune disease. Its pathology is not certain, and effective drugs with less toxicity have not been established. The establishment and application of animal models are effective methods for RA research, especially using animal models similar to humans. Arthritis is more heterogeneous, and this is an important starting point when discussing animal models for arthritis. Animal models are instrumental in understanding the etiology and pathogenetic mechanisms of RA. Appropriate animal models should be selected according to experiments because they have different traits. Various methods have been applied to induce arthritis in animal experimental models, which have provided important insights into the etiopathogenetic mechanisms of human RA. This review was written to give a broad introduction of the current stage of RA model and hope to offer beneficial help for RA-related research.

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Acknowledgements

This research was supported by National Natural Foundation of China (Support number: 81000786) and Shenzhen foundation (Number: 201103348)

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Authors and Affiliations

  1. Center for Translational Medicine Research and Development, Shen Zhen Institute of Advanced Technology, Chinese Academy of Science, Shen Zhen, Guangdong, 518055, China

    Yiping Hu, Wenxiang Cheng, Ye Yue, Jinchao Li & Peng Zhang

  2. The Department of Rheumatology, The Second Clinical Medical College, Ji’Nan University, Shen Zhen, Guangdong, 518055, China

    Wenhong Cai

  3. Shenzhen University Town, 1068 Xueyuan Avenue, Shenzhen, China

    Peng Zhang

Authors
  1. Yiping Hu
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  2. Wenxiang Cheng
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  3. Wenhong Cai
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  4. Ye Yue
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  5. Jinchao Li
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  6. Peng Zhang
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Correspondence to Peng Zhang.

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Hu, Y., Cheng, W., Cai, W. et al. Advances in research on animal models of rheumatoid arthritis. Clin Rheumatol 32, 161–165 (2013). https://doi.org/10.1007/s10067-012-2041-1

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  • DOI: https://doi.org/10.1007/s10067-012-2041-1

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