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18F-FDG PET as a diagnostic procedure in large vessel vasculitis—a controlled, blinded re-examination of routine PET scans

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Abstract

Large vessel vasculitis can be visualized by 18F-FDG positron emission tomography (PET). However, the diagnostic value of 18F-FDG PET is yet to be determined. We therefore performed a study to evaluate this technique for the diagnosis of giant cell arteritis (GCA) and Takayasu arteritis (TA). Patients with GCA or TA, who fulfilled the American College of Rheumatology (ACR) criteria and also had a pathologic PET scan in clinical routine, were selected. These PET scans, as well as PET scans obtained from age- and sex-matched control patients, were independently re-evaluated by two experienced nuclear medicine experts. PET scans of 20 patients (17 GCA, 3 TA) and 20 controls were evaluated. In 85% of the examinations, both observers agreed on the diagnosis or exclusion of vasculitis. Specificity was calculated with 80% and sensitivity with 65%, yielding an overall diagnostic accuracy of 72%. The mean maximum standardized uptake values (SUVmax) of the subclavian region was significantly higher in vasculitis than in control patients (2.77 ± 1.02 vs 2.09 ± 0.64; difference 0.69; CI95%: 0.14–1.24, p = 0.0161). SUVmax of the iliacal regions did not differ significantly. Receiver- operating characteristics (ROC) analysis revealed the highest sensitivity of 90% (CI95%: 68–99%) and specificity of 45% (CI95%: 23–69%) for a SUVmax cut-off point of 1.78 (AUC 0.72, (CI95%: 0.56–0.86). PET findings are reproducible and independent of the observer. The low sensitivity and specificity indicate that enhanced vascular uptake might be overrated if clinical details are suggestive for vasculitis. Therefore, the diagnosis of large vessel vasculitis should not be based on PET findings only.

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Notes

  1. (1) Age 50 years or older, (2) new-onset localized headache, (3) temporal artery tenderness or decreased temporal artery pulse, (4) erythrocyte sedimentation rate of at least 50 mm/h, (5) abnormal artery biopsy specimen characterized by mononuclear infiltration or granulomatous inflammation [22].

  2. (1) Age at disease onset in year ≤40 years, (2) claudication of extremities, (3) decreased brachial artery pulse, (4) difference of ≥10 mm Hg in systolic blood pressure between arms, (5) bruit audible on auscultation over one or both subclavian arteries or abdominal aorta, (6) arteriogram abnormality [23].

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Authors and Affiliations

  1. Department of Internal Medicine I, University Medical Center Regensburg, Franz-Josef-Strauss-Allee 11, 93053, Regensburg, Germany

    Petra Lehmann, Peter Haerle, Boris Ehrenstein & Martin Fleck

  2. Department of Nuclear Medicine, University Medical Center Regensburg, Regensburg, Germany

    Sarah Buchtala, Nelli Achajew, Hamid Lighvani & Joerg Marienhagen

  3. Department of Rheumatology and Physical Therapy, St. Vincenz and Elisabeth Hospital, Mainz, Germany

    Peter Haerle

  4. Department of Rheumatology and Clinical Immunology, Asklepios Hospital, Bad Abbach, Germany

    Martin Fleck

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  1. Petra Lehmann
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  2. Sarah Buchtala
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Correspondence to Petra Lehmann.

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Lehmann, P., Buchtala, S., Achajew, N. et al. 18F-FDG PET as a diagnostic procedure in large vessel vasculitis—a controlled, blinded re-examination of routine PET scans. Clin Rheumatol 30, 37–42 (2011). https://doi.org/10.1007/s10067-010-1598-9

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  • DOI: https://doi.org/10.1007/s10067-010-1598-9

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