Abstract
The proliferation of mesangial cells (MC) in the presence of glutamine (0–20 mM) was determined in both low (5 mM) and high (25 mM) glucose-containing medium. Glutamine in a high glucose (HG) environment increased cell proliferation in a dose-dependent manner. Inhibition of glutamine:fructose 6-phosphate amidotransferase (GFAT) and of phosphodiesterase significantly reduced glutamine-induced proliferation. Supraphysiologic levels of glutamine increase MC proliferation in a HG milieu via GFAT and cAMP-dependent pathways, suggesting that glutamine could pose a risk for diabetic nephropathy.
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Lagranha, C.J., Doi, S.Q., Pithon-Curi, T.C. et al. Glutamine enhances glucose-induced mesangial cell proliferation. Amino Acids 34, 683–685 (2008). https://doi.org/10.1007/s00726-007-0002-9
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DOI: https://doi.org/10.1007/s00726-007-0002-9