Abstract.
Epithelia lining the proximal convoluted epithelium and the visceral yolk sac in rodents are characterized by their ability to internalize and degrade many proteins facing their apical pole. It has become apparent over the last decade that this property is mediated through a very high endocytic activity and the expression of at least two distinct multiligand receptors, cubilin and megalin, characterized by the accumulation of ligand-binding units, LDL receptor class A repeats and CUB domains, respectively. We review here evidence that both receptors are involved in proximal tubule function and embryonic development.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Author information
Authors and Affiliations
Additional information
Electronic Publication
Rights and permissions
About this article
Cite this article
Christensen, E.I., Verroust, P.J. Megalin and cubilin, role in proximal tubule function and during development. Pediatr Nephrol 17, 993–999 (2002). https://doi.org/10.1007/s00467-002-0956-5
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/s00467-002-0956-5