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Prognostic value of 18F-FDG PET-CT metabolic index for nasopharyngeal carcinoma

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Abstract

Purpose

The purpose of this study was to evaluate the prognostic value of metabolic tumor volume (MTV) and metabolic index (MI) from fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) in patients with nasopharyngeal carcinoma (NPC).

Methods

From October 2002 to July 2004, 41 patients with NPC who underwent 18F-FDG PET-CT scan before and after radiotherapy were reviewed retrospectively. All patients received intensity-modulated radiotherapy using 6MV X-rays. We examined the association of MTV and the results of long-term follow-up of the patients.

Results

Patients having tumors with an MTV below 30 cm3 had significantly better 5-year overall survival (OS) (84.6:46.7%, P = 0.006) and disease-free survival (DFS) (73.1:40.0%, P = 0.014) than patients with an MTV of 30 cm3 or greater. And the patients with MI below 130 had significantly higher 5-year OS (88.0:43.8%, P = 0.002) and DFS (76.0:37.5%, P = 0.005) than other patients. In the Cox multivariate analysis, MI and metabolic response (MR) were predictive of DFS, and we did not find a significant relationship between standard uptake value (SUV) and OS or DFS.

Conclusions

The present study shows that tumor volume parameters, especially the combination of MTV and SUV in the “metabolic index”, are valuable for predicting long-term survival. High MI may be useful for identifying patients requiring more aggressive treatment.

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Acknowledgments

The authors thank Dr. Huiqing Li and Jinsong Zheng for their assistance with this paper.

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Authors and Affiliations

  1. Department of Radiation Oncology, Shandong Tumor Hospital and Institute, Jiyan Road 440, 250117, Jinan, Shandong, China

    Peng Xie, Jin-Bo Yue, Han-xi Zhao, Xin-Dong Sun, Li Kong & Jin-Ming Yu

  2. Department of Nuclear Medicine, Shandong Tumor Hospital and Institute, 250117, Jinan, China

    Zheng Fu

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  1. Peng Xie
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  2. Jin-Bo Yue
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  3. Han-xi Zhao
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  4. Xin-Dong Sun
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  5. Li Kong
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  7. Jin-Ming Yu
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Correspondence to Jin-Ming Yu.

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Xie, P., Yue, JB., Zhao, Hx. et al. Prognostic value of 18F-FDG PET-CT metabolic index for nasopharyngeal carcinoma. J Cancer Res Clin Oncol 136, 883–889 (2010). https://doi.org/10.1007/s00432-009-0729-7

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  • DOI: https://doi.org/10.1007/s00432-009-0729-7

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